Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

Renate M. Winkels, Lieve Van Brakel, Harm Van Baar, Robert B. Beelman, Fränzel J.B. Van Duijnhoven, Anne Geijsen, Henk K. Van Halteren, Bibi M.E. Hansson, John P. Richie, Dongxiao Sun, Evertine Wesselink, Moniek Van Zutphen, Ellen Kampman, Dieuwertje E. Kok

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET)–a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy. Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 μg/ml (7.2–15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy. Results: Prevalence of total and sensory peripheral neuropathy were both 81%. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy. Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations.

LanguageEnglish
JournalNutrition and Cancer
DOIs
Publication statusE-pub ahead of print - 12 Jul 2019

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Ergothioneine
Peripheral Nervous System Diseases
Colorectal Neoplasms
Drug Therapy
Sample Size
Linear Models
Theoretical Models
Antioxidants

Cite this

@article{ab059685f3634b5498d6067d39832562,
title = "Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?",
abstract = "Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET)–a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy. Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 μg/ml (7.2–15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy. Results: Prevalence of total and sensory peripheral neuropathy were both 81{\%}. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy. Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations.",
author = "Winkels, {Renate M.} and {Van Brakel}, Lieve and {Van Baar}, Harm and Beelman, {Robert B.} and {Van Duijnhoven}, {Fr{\"a}nzel J.B.} and Anne Geijsen and {Van Halteren}, {Henk K.} and Hansson, {Bibi M.E.} and Richie, {John P.} and Dongxiao Sun and Evertine Wesselink and {Van Zutphen}, Moniek and Ellen Kampman and Kok, {Dieuwertje E.}",
year = "2019",
month = "7",
day = "12",
doi = "10.1080/01635581.2019.1637005",
language = "English",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Taylor & Francis",

}

Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy? / Winkels, Renate M.; Van Brakel, Lieve; Van Baar, Harm; Beelman, Robert B.; Van Duijnhoven, Fränzel J.B.; Geijsen, Anne; Van Halteren, Henk K.; Hansson, Bibi M.E.; Richie, John P.; Sun, Dongxiao; Wesselink, Evertine; Van Zutphen, Moniek; Kampman, Ellen; Kok, Dieuwertje E.

In: Nutrition and Cancer, 12.07.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

AU - Winkels, Renate M.

AU - Van Brakel, Lieve

AU - Van Baar, Harm

AU - Beelman, Robert B.

AU - Van Duijnhoven, Fränzel J.B.

AU - Geijsen, Anne

AU - Van Halteren, Henk K.

AU - Hansson, Bibi M.E.

AU - Richie, John P.

AU - Sun, Dongxiao

AU - Wesselink, Evertine

AU - Van Zutphen, Moniek

AU - Kampman, Ellen

AU - Kok, Dieuwertje E.

PY - 2019/7/12

Y1 - 2019/7/12

N2 - Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET)–a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy. Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 μg/ml (7.2–15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy. Results: Prevalence of total and sensory peripheral neuropathy were both 81%. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy. Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations.

AB - Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET)–a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy. Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 μg/ml (7.2–15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy. Results: Prevalence of total and sensory peripheral neuropathy were both 81%. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy. Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations.

U2 - 10.1080/01635581.2019.1637005

DO - 10.1080/01635581.2019.1637005

M3 - Article

JO - Nutrition and Cancer

T2 - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

ER -