Urban resilience is a prominent topic in landscape architecture and urban design that comprises systemic design approaches. While contemporary design discourses acknowledge this concept, the operationalization of urban resilience remains challenging. The different components of urban resilience need to be blended in robust and feasible spatial forms. This calls for holistic design frameworks targeted at operationalizing urban resilience. In response to this challenge, this chapter proposes the Applied Urban Resilience Framework. This is a conceptual framework for addressing the complexity of the urban environment subjected to shocks and stresses, through systemic approaches led by spatial design.