Applications of hydrophobins

current state and perspectives

H.A.B. Wösten, Karin Scholtmeijer

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

Hydrophobins are proteins exclusively produced by filamentous fungi. They self-assemble at hydrophilic-hydrophobic interfaces into an amphipathic film. This protein film renders hydrophobic surfaces of gas bubbles, liquids, or solid materials wettable, while hydrophilic surfaces can be turned hydrophobic. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to disperse hydrophobic materials; to stabilize foam in food products; and to immobilize enzymes, peptides, antibodies, cells, and anorganic molecules on surfaces. At the same time, they may be used to prevent binding of molecules. Furthermore, hydrophobins have therapeutic value as immunomodulators and can been used to produce recombinant proteins.

Original languageEnglish
Pages (from-to)1587-1597
JournalApplied Microbiology and Biotechnology
Volume99
Issue number4
DOIs
Publication statusPublished - 2015

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Immunologic Factors
Recombinant Proteins
Proteins
Fungi
Gases
Food
Peptides
Antibodies
Enzymes
Therapeutics

Keywords

  • Applications
  • Hydrophobins
  • Self-assembly
  • Surface modification

Cite this

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Applications of hydrophobins : current state and perspectives. / Wösten, H.A.B.; Scholtmeijer, Karin.

In: Applied Microbiology and Biotechnology, Vol. 99, No. 4, 2015, p. 1587-1597.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Applications of hydrophobins

T2 - current state and perspectives

AU - Wösten, H.A.B.

AU - Scholtmeijer, Karin

PY - 2015

Y1 - 2015

N2 - Hydrophobins are proteins exclusively produced by filamentous fungi. They self-assemble at hydrophilic-hydrophobic interfaces into an amphipathic film. This protein film renders hydrophobic surfaces of gas bubbles, liquids, or solid materials wettable, while hydrophilic surfaces can be turned hydrophobic. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to disperse hydrophobic materials; to stabilize foam in food products; and to immobilize enzymes, peptides, antibodies, cells, and anorganic molecules on surfaces. At the same time, they may be used to prevent binding of molecules. Furthermore, hydrophobins have therapeutic value as immunomodulators and can been used to produce recombinant proteins.

AB - Hydrophobins are proteins exclusively produced by filamentous fungi. They self-assemble at hydrophilic-hydrophobic interfaces into an amphipathic film. This protein film renders hydrophobic surfaces of gas bubbles, liquids, or solid materials wettable, while hydrophilic surfaces can be turned hydrophobic. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to disperse hydrophobic materials; to stabilize foam in food products; and to immobilize enzymes, peptides, antibodies, cells, and anorganic molecules on surfaces. At the same time, they may be used to prevent binding of molecules. Furthermore, hydrophobins have therapeutic value as immunomodulators and can been used to produce recombinant proteins.

KW - Applications

KW - Hydrophobins

KW - Self-assembly

KW - Surface modification

U2 - 10.1007/s00253-014-6319-x

DO - 10.1007/s00253-014-6319-x

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VL - 99

SP - 1587

EP - 1597

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

SN - 0175-7598

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