Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Jolanda H.M. Van Bilsen, Edyta Sienkiewicz-Szłapka, Daniel Lozano-Ojalvo, Linette E.M. Willemsen, Celia M. Antunes, Elena Molina, Joost J. Smit, Barbara Wróblewska, Harry J. Wichers, Edward F. Knol, Gregory S. Ladics, Raymond H.H. Pieters, Sandra Denery-Papini, Yvonne M. Vissers, Simona L. Bavaro, Colette Larré, Kitty C.M. Verhoeckx, Erwin L. Roggen

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)

Abstract

Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). Main body: The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell-cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential. Conclusion: The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.
Original languageEnglish
Article number13
JournalClinical and Translational Allergy
Volume7
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Food
Proteins
Food Hypersensitivity
In Vitro Techniques
Cell Communication
Homeostasis
Public Health
Biomarkers
Skin
Population

Keywords

  • Adverse outcome pathway
  • Food allergy
  • Food proteins
  • Key event relations
  • Key events
  • Mechanistic understanding
  • Molecular initiating event
  • Sensitization

Cite this

Van Bilsen, Jolanda H.M. ; Sienkiewicz-Szłapka, Edyta ; Lozano-Ojalvo, Daniel ; Willemsen, Linette E.M. ; Antunes, Celia M. ; Molina, Elena ; Smit, Joost J. ; Wróblewska, Barbara ; Wichers, Harry J. ; Knol, Edward F. ; Ladics, Gregory S. ; Pieters, Raymond H.H. ; Denery-Papini, Sandra ; Vissers, Yvonne M. ; Bavaro, Simona L. ; Larré, Colette ; Verhoeckx, Kitty C.M. ; Roggen, Erwin L. / Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins. In: Clinical and Translational Allergy. 2017 ; Vol. 7, No. 1.
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title = "Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins",
abstract = "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). Main body: The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell-cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential. Conclusion: The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.",
keywords = "Adverse outcome pathway, Food allergy, Food proteins, Key event relations, Key events, Mechanistic understanding, Molecular initiating event, Sensitization",
author = "{Van Bilsen}, {Jolanda H.M.} and Edyta Sienkiewicz-Szłapka and Daniel Lozano-Ojalvo and Willemsen, {Linette E.M.} and Antunes, {Celia M.} and Elena Molina and Smit, {Joost J.} and Barbara Wr{\'o}blewska and Wichers, {Harry J.} and Knol, {Edward F.} and Ladics, {Gregory S.} and Pieters, {Raymond H.H.} and Sandra Denery-Papini and Vissers, {Yvonne M.} and Bavaro, {Simona L.} and Colette Larr{\'e} and Verhoeckx, {Kitty C.M.} and Roggen, {Erwin L.}",
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language = "English",
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Van Bilsen, JHM, Sienkiewicz-Szłapka, E, Lozano-Ojalvo, D, Willemsen, LEM, Antunes, CM, Molina, E, Smit, JJ, Wróblewska, B, Wichers, HJ, Knol, EF, Ladics, GS, Pieters, RHH, Denery-Papini, S, Vissers, YM, Bavaro, SL, Larré, C, Verhoeckx, KCM & Roggen, EL 2017, 'Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins' Clinical and Translational Allergy, vol. 7, no. 1, 13. https://doi.org/10.1186/s13601-017-0152-0

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins. / Van Bilsen, Jolanda H.M.; Sienkiewicz-Szłapka, Edyta; Lozano-Ojalvo, Daniel; Willemsen, Linette E.M.; Antunes, Celia M.; Molina, Elena; Smit, Joost J.; Wróblewska, Barbara; Wichers, Harry J.; Knol, Edward F.; Ladics, Gregory S.; Pieters, Raymond H.H.; Denery-Papini, Sandra; Vissers, Yvonne M.; Bavaro, Simona L.; Larré, Colette; Verhoeckx, Kitty C.M.; Roggen, Erwin L.

In: Clinical and Translational Allergy, Vol. 7, No. 1, 13, 2017.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

AU - Van Bilsen, Jolanda H.M.

AU - Sienkiewicz-Szłapka, Edyta

AU - Lozano-Ojalvo, Daniel

AU - Willemsen, Linette E.M.

AU - Antunes, Celia M.

AU - Molina, Elena

AU - Smit, Joost J.

AU - Wróblewska, Barbara

AU - Wichers, Harry J.

AU - Knol, Edward F.

AU - Ladics, Gregory S.

AU - Pieters, Raymond H.H.

AU - Denery-Papini, Sandra

AU - Vissers, Yvonne M.

AU - Bavaro, Simona L.

AU - Larré, Colette

AU - Verhoeckx, Kitty C.M.

AU - Roggen, Erwin L.

PY - 2017

Y1 - 2017

N2 - Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). Main body: The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell-cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential. Conclusion: The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.

AB - Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). Main body: The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell-cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential. Conclusion: The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.

KW - Adverse outcome pathway

KW - Food allergy

KW - Food proteins

KW - Key event relations

KW - Key events

KW - Mechanistic understanding

KW - Molecular initiating event

KW - Sensitization

U2 - 10.1186/s13601-017-0152-0

DO - 10.1186/s13601-017-0152-0

M3 - Review article

VL - 7

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

IS - 1

M1 - 13

ER -