Apolipoprotein E Genotype Modifies the Association between Midlife Lung Function and Cognitive Function in Old Age

E.J. Giltay, A. Nissinen, S. Giampaoli, D. Kromhout

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Background/Aims: Because poor lung function may be a risk factor for cognitive decline, we aimed to test the association of respiratory function with cognitive function and dementia later in life, as well as potential effect modification by APOE 4 carrier status. Methods: In a prospective population-based cohort study, forced vital capacity and forced expiratory flow were measured around 1965 in 857 men aged 45-64 years (394 from Finland, 208 from The Netherlands, and 255 from Italy). The Mini-Mental State Examination scores around 1990, 1995 and 2000 were analyzed using multilevel regression models and the Clinical Dementia Rating score around 1990 using multinomial logistic regression analyses. Results: Midlife lung function was positively associated with cognitive function in old age in APOE 4 non-carriers, but not in carriers (p <0.05 for interaction). In Finland and Italy, 18.6% had questionable to mild dementia and 2.8% moderate to severe dementia after 25 years of follow-up. Dementia was inversely related to midlife lung function in APOE 4 non-carriers, but not in carriers (p <0.05 for interaction). Conclusions: Small lung volumes were prospectively associated with an increased risk for poor cognitive function and dementia in non-carriers of the APOE 4 gene.
Original languageEnglish
Pages (from-to)433-441
JournalDementia and Geriatric Cognitive Disorders
Volume28
Issue number5
DOIs
Publication statusPublished - 2009

Keywords

  • alzheimers-disease
  • pulmonary-function
  • risk-factors
  • atherosclerosis risk
  • respiratory-function
  • life expectancy
  • apoe epsilon-4
  • birth cohort
  • dementia
  • health

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