Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.

M.A.J.S. van Boekel, A.R. Goeptar, G.M. Alink

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein.
Original languageEnglish
Pages (from-to)85-87
JournalCancer Letters
Volume114
DOIs
Publication statusPublished - 1997

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