Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.

M.A.J.S. van Boekel; A.R. Goeptar; G.M. Alink

doi:10.1016/S0304-3835(97)04630-2

Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.

M.A.J.S. van Boekel, A.R. Goeptar, G.M. Alink

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein.

Original language	English
Pages (from-to)	85-87
Journal	Cancer Letters
Volume	114
DOIs	https://doi.org/10.1016/S0304-3835(97)04630-2
Publication status	Published - 1997

Access to Document

10.1016/S0304-3835(97)04630-2

Fingerprint Dive into the research topics of 'Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.'. Together they form a unique fingerprint.

Cite this

@article{b658fbc4af6741c0af3f581895dccf89,

title = "Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.",

abstract = "The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein.",

author = "{van Boekel}, M.A.J.S. and A.R. Goeptar and G.M. Alink",

year = "1997",

doi = "10.1016/S0304-3835(97)04630-2",

language = "English",

volume = "114",

pages = "85--87",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier",

}

TY - JOUR

T1 - Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay.

AU - van Boekel, M.A.J.S.

AU - Goeptar, A.R.

AU - Alink, G.M.

PY - 1997

Y1 - 1997

N2 - The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein.

AB - The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein.

U2 - 10.1016/S0304-3835(97)04630-2

DO - 10.1016/S0304-3835(97)04630-2

M3 - Article

VL - 114

SP - 85

EP - 87

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

ER -