Antimicrobial Efficacy of a Vegetable Oil Plasticizer in PVC Matrices

Greta Bajetto, Sara Scutera, Francesca Menotti, Giuliana Banche, Giuseppe Chiaradia, Caterina Turesso, Marco De Andrea, Marta Vallino, Daan van Es, Matteo Biolatti*, Valentina Dell’Oste, Tiziana Musso

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The growing prevalence of bacterial and viral infections, highlighted by the recent COVID-19 pandemic, urgently calls for new antimicrobial strategies. To this end, we have synthesized and characterized a novel fatty acid epoxy-ester plasticizer for polymers, named GDE. GDE is not only sustainable and user-friendly but also demonstrates superior plasticizing properties, while its epoxy components improve the heat stability of PVC-based matrices. A key feature of GDE is its ability to confer antimicrobial properties to surfaces. Indeed, upon contact, this material can effectively kill enveloped viruses, such as herpes simplex virus type 1 (HSV-1) and the β-coronavirus prototype HCoV-OC43, but it is ineffective against nonenveloped viruses like human adenovirus (HAdV). Further analysis using transmission electron microscopy (TEM) on HSV-1 virions exposed to GDE showed significant structural damage, indicating that GDE can interfere with the viral envelope, potentially causing leakage. Moreover, GDE demonstrates antibacterial activity, albeit to a lesser extent, against notorious pathogens such as Staphylococcus aureus and Escherichia coli. Overall, this newly developed plasticizer shows significant potential as an antimicrobial agent suitable for use in both community and healthcare settings to curb the spread of infections caused by microorganisms contaminating physical surfaces.

Original languageEnglish
Article number1046
JournalPolymers
Volume16
Issue number8
DOIs
Publication statusPublished - Apr 2024

Keywords

  • antiviral and antibacterial polymers
  • biomaterials
  • medical devices
  • plasticizers
  • polyvinyl chloride (PVC)
  • vegetable oils

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