Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 63-80 |
| Journal | Mediators of Inflammation |
| Volume | 2005 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- pattern-recognition receptors
- mushroom phellinus-linteus
- agaricus-blazei-murill
- natural-killer-cells
- tumor-bearing mice
- collagen-induced arthritis
- protein-tyrosine kinase
- water-soluble extract
- cultured fruit body
- cd4(+) t-cells
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Antiinflammatory and immunomodulating properties of fungal metabolites. / Lull Noguera, C.; Wichers, H.J.; Savelkoul, H.F.J.
In: Mediators of Inflammation, Vol. 2005, No. 2, 2005, p. 63-80.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Antiinflammatory and immunomodulating properties of fungal metabolites
AU - Lull Noguera, C.
AU - Wichers, H.J.
AU - Savelkoul, H.F.J.
PY - 2005
Y1 - 2005
N2 - We discuss current information on the ability of extracts and isolated metabolites from mushrooms to modulate immune responses. This can result in a more enhanced innate and acquired disease resistance. The major immunomodulating effects of these active substances derived from mushrooms include mitogenicity and activation of immune effector cells, such as lymphocytes, macrophages, and natural killer cells, resulting in the production of cytokines, including interleukins (ILs), tumor necrosis factor alpha (TNF)-¿, and interferon gamma (INF)-¿. In particular, the ability of selective mushroom extracts to modulate the differentiation capacity of CD4+ T cells to mature into TH1 and/or TH2 subsets will be discussed. As a consequence these extracts will have profound effects in particular diseases, like chronic autoimmune TH1-mediated or allergic TH2-mediated diseases. Immunosuppressive effects by mushroom components have also been observed. The therapeutic effects of mushrooms, such as anticancer activity, suppression of autoimmune diseases, and allergy have been associated with their immunomodulating effects. However, further studies are needed to determine the molecular mechanisms of the immunomodulating effects of mushrooms metabolites both individually and in complex mixtures, for example, extracts
AB - We discuss current information on the ability of extracts and isolated metabolites from mushrooms to modulate immune responses. This can result in a more enhanced innate and acquired disease resistance. The major immunomodulating effects of these active substances derived from mushrooms include mitogenicity and activation of immune effector cells, such as lymphocytes, macrophages, and natural killer cells, resulting in the production of cytokines, including interleukins (ILs), tumor necrosis factor alpha (TNF)-¿, and interferon gamma (INF)-¿. In particular, the ability of selective mushroom extracts to modulate the differentiation capacity of CD4+ T cells to mature into TH1 and/or TH2 subsets will be discussed. As a consequence these extracts will have profound effects in particular diseases, like chronic autoimmune TH1-mediated or allergic TH2-mediated diseases. Immunosuppressive effects by mushroom components have also been observed. The therapeutic effects of mushrooms, such as anticancer activity, suppression of autoimmune diseases, and allergy have been associated with their immunomodulating effects. However, further studies are needed to determine the molecular mechanisms of the immunomodulating effects of mushrooms metabolites both individually and in complex mixtures, for example, extracts
KW - pattern-recognition receptors
KW - mushroom phellinus-linteus
KW - agaricus-blazei-murill
KW - natural-killer-cells
KW - tumor-bearing mice
KW - collagen-induced arthritis
KW - protein-tyrosine kinase
KW - water-soluble extract
KW - cultured fruit body
KW - cd4(+) t-cells
U2 - 10.1155/MI.2005.63
DO - 10.1155/MI.2005.63
M3 - Review article
VL - 2005
SP - 63
EP - 80
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
IS - 2
ER -