Antiinflammatory and immunomodulating properties of fungal metabolites

C. Lull Noguera, H.J. Wichers, H.F.J. Savelkoul

Research output: Contribution to journalArticleAcademicpeer-review

248 Citations (Scopus)

Abstract

We discuss current information on the ability of extracts and isolated metabolites from mushrooms to modulate immune responses. This can result in a more enhanced innate and acquired disease resistance. The major immunomodulating effects of these active substances derived from mushrooms include mitogenicity and activation of immune effector cells, such as lymphocytes, macrophages, and natural killer cells, resulting in the production of cytokines, including interleukins (ILs), tumor necrosis factor alpha (TNF)-¿, and interferon gamma (INF)-¿. In particular, the ability of selective mushroom extracts to modulate the differentiation capacity of CD4+ T cells to mature into TH1 and/or TH2 subsets will be discussed. As a consequence these extracts will have profound effects in particular diseases, like chronic autoimmune TH1-mediated or allergic TH2-mediated diseases. Immunosuppressive effects by mushroom components have also been observed. The therapeutic effects of mushrooms, such as anticancer activity, suppression of autoimmune diseases, and allergy have been associated with their immunomodulating effects. However, further studies are needed to determine the molecular mechanisms of the immunomodulating effects of mushrooms metabolites both individually and in complex mixtures, for example, extracts
Original languageEnglish
Pages (from-to)63-80
JournalMediators of Inflammation
Volume2005
Issue number2
DOIs
Publication statusPublished - 2005

Keywords

  • pattern-recognition receptors
  • mushroom phellinus-linteus
  • agaricus-blazei-murill
  • natural-killer-cells
  • tumor-bearing mice
  • collagen-induced arthritis
  • protein-tyrosine kinase
  • water-soluble extract
  • cultured fruit body
  • cd4(+) t-cells

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