Antagonistic interactions peak at intermediate genetic similarity

S.E. Schoustra, J. Dench, R. Dali, S.D. Aaron, R.K. Kassen

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Background Bacteria excrete costly toxins to defend their ecological niche. The evolution of such antagonistic interactions between individuals is expected to depend on both the social environment and the strength of resource competition. Antagonism is expected to be weak among highly similar genotypes because most individuals are immune to antagonistic agents and among dissimilar genotypes because these are unlikely to be competing for the same resources and antagonism should not yield much benefit. The strength of antagonism is therefore expected to peak at intermediate genetic distance. Results We studied the ability of laboratory strains of Pseudomonas aeruginosa to prevent growth of 55 different clinical P. aeruginosa isolates derived from cystic fibrosis patients. Genetic distance was determined using genetic fingerprints. We found that the strength of antagonism was maximal among genotypes of intermediate genetic distance and we show that genetic distance and resource use are linked. Conclusions Our results suggest that the importance of social interactions like antagonism may be modulated by the strength of resource competition
Original languageEnglish
Article number40
JournalBMC Microbiology
Volume12
DOIs
Publication statusPublished - 2012

Fingerprint

Genotype
Pseudomonas aeruginosa
Aptitude
Social Environment
Dermatoglyphics
Interpersonal Relations
Cystic Fibrosis
Growth

Keywords

  • cystic-fibrosis patients
  • staphylococcus-aureus
  • bacteriocins
  • evolution
  • spite
  • virulence
  • sequence
  • ecology
  • pyocins
  • pao1

Cite this

Schoustra, S.E. ; Dench, J. ; Dali, R. ; Aaron, S.D. ; Kassen, R.K. / Antagonistic interactions peak at intermediate genetic similarity. In: BMC Microbiology. 2012 ; Vol. 12.
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Antagonistic interactions peak at intermediate genetic similarity. / Schoustra, S.E.; Dench, J.; Dali, R.; Aaron, S.D.; Kassen, R.K.

In: BMC Microbiology, Vol. 12, 40, 2012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Antagonistic interactions peak at intermediate genetic similarity

AU - Schoustra, S.E.

AU - Dench, J.

AU - Dali, R.

AU - Aaron, S.D.

AU - Kassen, R.K.

PY - 2012

Y1 - 2012

N2 - Background Bacteria excrete costly toxins to defend their ecological niche. The evolution of such antagonistic interactions between individuals is expected to depend on both the social environment and the strength of resource competition. Antagonism is expected to be weak among highly similar genotypes because most individuals are immune to antagonistic agents and among dissimilar genotypes because these are unlikely to be competing for the same resources and antagonism should not yield much benefit. The strength of antagonism is therefore expected to peak at intermediate genetic distance. Results We studied the ability of laboratory strains of Pseudomonas aeruginosa to prevent growth of 55 different clinical P. aeruginosa isolates derived from cystic fibrosis patients. Genetic distance was determined using genetic fingerprints. We found that the strength of antagonism was maximal among genotypes of intermediate genetic distance and we show that genetic distance and resource use are linked. Conclusions Our results suggest that the importance of social interactions like antagonism may be modulated by the strength of resource competition

AB - Background Bacteria excrete costly toxins to defend their ecological niche. The evolution of such antagonistic interactions between individuals is expected to depend on both the social environment and the strength of resource competition. Antagonism is expected to be weak among highly similar genotypes because most individuals are immune to antagonistic agents and among dissimilar genotypes because these are unlikely to be competing for the same resources and antagonism should not yield much benefit. The strength of antagonism is therefore expected to peak at intermediate genetic distance. Results We studied the ability of laboratory strains of Pseudomonas aeruginosa to prevent growth of 55 different clinical P. aeruginosa isolates derived from cystic fibrosis patients. Genetic distance was determined using genetic fingerprints. We found that the strength of antagonism was maximal among genotypes of intermediate genetic distance and we show that genetic distance and resource use are linked. Conclusions Our results suggest that the importance of social interactions like antagonism may be modulated by the strength of resource competition

KW - cystic-fibrosis patients

KW - staphylococcus-aureus

KW - bacteriocins

KW - evolution

KW - spite

KW - virulence

KW - sequence

KW - ecology

KW - pyocins

KW - pao1

U2 - 10.1186/1471-2180-12-40

DO - 10.1186/1471-2180-12-40

M3 - Article

VL - 12

JO - BMC Microbiology

JF - BMC Microbiology

SN - 1471-2180

M1 - 40

ER -