Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level

Michael Schon, Catherine Baxter, Congyao Xu, Balaji Enugutti, Michael D. Nodine, Caroline Dean*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Quantitative variation in expression of the Arabidopsis floral repressor FLC influences whether plants overwinter before flowering, or have a rapid cycling habit enabling multiple generations a year. Genetic analysis has identified activators and repressors of FLC expression but how they interact to set expression level is poorly understood. Here, we show that antagonistic functions of the FLC activator FRIGIDA (FRI) and the repressor FCA, at a specific stage of embryo development, determine FLC expression and flowering. FRI antagonizes an FCA-induced proximal polyadenylation to increase FLC expression and delay flowering. Sector analysis shows that FRI activity during the early heart stage of embryo development maximally delays flowering. Opposing functions of cotranscriptional regulators during an early embryonic developmental window thus set FLC expression levels and determine flowering time. Results Regulation of FLC Polyadenylation Site Usage during Embryogenesis.

Original languageEnglish
Article numbere2102753118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number17
DOIs
Publication statusPublished - 27 Apr 2021

Fingerprint

Dive into the research topics of 'Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level'. Together they form a unique fingerprint.

Cite this