Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae

G. Wang, Y.T. Qiu, T. Lu, H.W. Kwon, R.J. Pitts, J.J.A. van Loon, W. Takken, L.J. Zwiebel

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Scopus)

Abstract

Heat sensitivity is a sensory modality that plays a critical role in close-range host-seeking behaviors of adult female Anopheles gambiae, the principal Afrotropical vector for human malaria. An essential step in this activity is the ability to discriminate and respond to increases in environmental temperature gradients through the process of peripheral thermoreception. Here, we report on the characterization of the anopheline homolog of the transient receptor potential (TRP) A1/ANKTM1 channel that is consistent with its role as a heat-sensor in host-seeking adult female mosquitoes. We identify a set of distal antennal sensory structures that specifically respond to temperature gradients and express AgTRPA1. Functional characterization of AgTRPA1 in Xenopus oocytes supports its role in the molecular transduction of temperature gradients in An. gambiae, providing a basis for targeting mosquito heat responses as a means toward reducing malaria transmission
Original languageEnglish
Pages (from-to)967-974
JournalEuropean Journal of Neuroscience
Volume30
Issue number6
DOIs
Publication statusPublished - 2009

Keywords

  • fine-structure
  • drosophila-melanogaster
  • malaria mosquito
  • temperature
  • receptors
  • behavior
  • warm
  • coeloconica
  • culicidae
  • responses

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