Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity

Robin van Eenige; W. in het Panhuis; Milena Schönke; Céline Jouffe; Thomas H. Devilee; R. Siebeler; Trea C.M. Streefland; Hetty C.M. Sips; Amanda C.M. Pronk; Ruben Vorderman; Haillang Mei; Jan Bert van Klinken; Michel van Weeghel; Nina H. Uhlenhaut; A.H. Kersten; Patrick Rensen; Sander Kooijman

doi:10.54985/peeref.2306p7202701

Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity

Robin van Eenige, W. in het Panhuis, Milena Schönke, Céline Jouffe, Thomas H. Devilee, R. Siebeler, Trea C.M. Streefland, Hetty C.M. Sips, Amanda C.M. Pronk, Ruben Vorderman, Haillang Mei, Jan Bert van Klinken, Michel van Weeghel, Nina H. Uhlenhaut, A.H. Kersten, Patrick Rensen, Sander Kooijman

Research output: Other contribution › Pamphlet

Abstract

Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and interestingly shows a strong day-night rhythm in glucose and triglyceride (TG)-derived FA-uptake (Van den Berg, Cell Rep 2018), peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity. BAT was collected from chow-fed male C57BL/6J mice at 3-hour intervals throughout the day, and RNA-sequencing, chromatin immunoprecipitation (ChIP)-sequencing, and lipidomics analyses were performed. Knockout and overexpression models were used to study causal relationships in diurnal lipid handling by BAT. Our findings highlight involvement of PPARγ and a crucial role of angiopoietin-like 4 (ANGPTL4) in mediating the day-night rhythm of TG-derived FA-uptake by BAT, and implicate that time of day should be considered when studying the metabolic benefits of targeting brown fat.

Original language	English
Publisher	Universiteit Leiden
Number of pages	1
DOIs	https://doi.org/10.54985/peeref.2306p7202701
Publication status	Published - 24 Jun 2023

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van Eenige, R., in het Panhuis, W., Schönke, M., Jouffe, C., Devilee, T. H., Siebeler, R., Streefland, T. C. M., Sips, H. C. M., Pronk, A. C. M., Vorderman, R., Mei, H., van Klinken, J. B., van Weeghel, M., Uhlenhaut, N. H., Kersten, A. H., Rensen, P., & Kooijman, S. (2023, Jun 24). Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity. Universiteit Leiden. https://doi.org/10.54985/peeref.2306p7202701

@misc{271d516cbb9e4d45aa049e9ebe88b381,

title = "Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity",

abstract = "Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and interestingly shows a strong day-night rhythm in glucose and triglyceride (TG)-derived FA-uptake (Van den Berg, Cell Rep 2018), peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity. BAT was collected from chow-fed male C57BL/6J mice at 3-hour intervals throughout the day, and RNA-sequencing, chromatin immunoprecipitation (ChIP)-sequencing, and lipidomics analyses were performed. Knockout and overexpression models were used to study causal relationships in diurnal lipid handling by BAT. Our findings highlight involvement of PPARγ and a crucial role of angiopoietin-like 4 (ANGPTL4) in mediating the day-night rhythm of TG-derived FA-uptake by BAT, and implicate that time of day should be considered when studying the metabolic benefits of targeting brown fat.",

author = "{van Eenige}, Robin and {in het Panhuis}, W. and Milena Sch{\"o}nke and C{\'e}line Jouffe and Devilee, {Thomas H.} and R. Siebeler and Streefland, {Trea C.M.} and Sips, {Hetty C.M.} and Pronk, {Amanda C.M.} and Ruben Vorderman and Haillang Mei and {van Klinken}, {Jan Bert} and {van Weeghel}, Michel and Uhlenhaut, {Nina H.} and A.H. Kersten and Patrick Rensen and Sander Kooijman",

year = "2023",

month = jun,

day = "24",

doi = "10.54985/peeref.2306p7202701",

language = "English",

publisher = "Universiteit Leiden",

address = "Netherlands",

type = "Other",

}

van Eenige, R, in het Panhuis, W, Schönke, M, Jouffe, C, Devilee, TH, Siebeler, R, Streefland, TCM, Sips, HCM, Pronk, ACM, Vorderman, R, Mei, H, van Klinken, JB, van Weeghel, M, Uhlenhaut, NH, Kersten, AH, Rensen, P & Kooijman, S 2023, Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity. Universiteit Leiden. https://doi.org/10.54985/peeref.2306p7202701

TY - GEN

T1 - Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity

AU - van Eenige, Robin

AU - in het Panhuis, W.

AU - Schönke, Milena

AU - Jouffe, Céline

AU - Devilee, Thomas H.

AU - Siebeler, R.

AU - Streefland, Trea C.M.

AU - Sips, Hetty C.M.

AU - Pronk, Amanda C.M.

AU - Vorderman, Ruben

AU - Mei, Haillang

AU - van Klinken, Jan Bert

AU - van Weeghel, Michel

AU - Uhlenhaut, Nina H.

AU - Kersten, A.H.

AU - Rensen, Patrick

AU - Kooijman, Sander

PY - 2023/6/24

Y1 - 2023/6/24

N2 - Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and interestingly shows a strong day-night rhythm in glucose and triglyceride (TG)-derived FA-uptake (Van den Berg, Cell Rep 2018), peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity. BAT was collected from chow-fed male C57BL/6J mice at 3-hour intervals throughout the day, and RNA-sequencing, chromatin immunoprecipitation (ChIP)-sequencing, and lipidomics analyses were performed. Knockout and overexpression models were used to study causal relationships in diurnal lipid handling by BAT. Our findings highlight involvement of PPARγ and a crucial role of angiopoietin-like 4 (ANGPTL4) in mediating the day-night rhythm of TG-derived FA-uptake by BAT, and implicate that time of day should be considered when studying the metabolic benefits of targeting brown fat.

AB - Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and interestingly shows a strong day-night rhythm in glucose and triglyceride (TG)-derived FA-uptake (Van den Berg, Cell Rep 2018), peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity. BAT was collected from chow-fed male C57BL/6J mice at 3-hour intervals throughout the day, and RNA-sequencing, chromatin immunoprecipitation (ChIP)-sequencing, and lipidomics analyses were performed. Knockout and overexpression models were used to study causal relationships in diurnal lipid handling by BAT. Our findings highlight involvement of PPARγ and a crucial role of angiopoietin-like 4 (ANGPTL4) in mediating the day-night rhythm of TG-derived FA-uptake by BAT, and implicate that time of day should be considered when studying the metabolic benefits of targeting brown fat.

U2 - 10.54985/peeref.2306p7202701

DO - 10.54985/peeref.2306p7202701

M3 - Pamphlet

PB - Universiteit Leiden

ER -

Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity

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