Analysis of the Tomato spotted wilt virus ambisense S RNA-encoded hairpin structure in translation

C. Geerts-Dimitriadou, Y.Y. Lu, C. Geertsema, R.W. Goldbach, R.J.M. Kormelink

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Abstract

The intergenic region (IR) of ambisense RNA segments from animal- and plant-infecting (-)RNA viruses functions as a bidirectional transcription terminator. The IR sequence of the Tomato spotted wilt virus (TSWV) ambisense S RNA contains stretches that are highly rich in A-residues and U-residues and is predicted to fold into a stable hairpin structure. The presence of this hairpin structure sequence in the 3' untranslated region (UTR) of TSWV mRNAs implies a possible role in translation.
Original languageEnglish
Article numbere31013
JournalPLoS ONE
Volume7
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • nonstructural protein nss
  • affecting transcription termination
  • tail-independent translation
  • cap-snatching mechanism
  • escherichia-coli rna
  • stem-loop structure
  • cdna-based rescue
  • messenger-rna
  • influenza-virus
  • intergenic region

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