Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

S. Kaul, H.L. Koo, J. Jenkins, M. Rizzo, T. Rooney, L.J. Tallon, T. Feldblyum, W. Nierman, M.I. Benito, X. Lin, W.J. Stiekema

Research output: Contribution to journalArticleAcademicpeer-review

6236 Citations (Scopus)


The flowering plant Arabidopsis thaliana is an important model system for identifying genes and determining their functions. Here we report the analysis of the genomic sequence of Arabidopsis. The sequenced regions cover 115.4 megabases of the 125-megabase genome and extend into centromeric regions. The evolution of Arabidopsis involved a whole-genome duplication, followed by subsequent gene loss and extensive local gene duplications, giving rise to a dynamic genome enriched by lateral gene transfer from a cyanobacterial-like ancestor of the plastid. The genome contains 25,498 genes encoding proteins from 11,000 families, similar to the functional diversity of Drosophila and Caenorhabditis elegans— the other sequenced multicellular eukaryotes. Arabidopsis has many families of new proteins but also lacks several common protein families, indicating that the sets of common proteins have undergone differential expansion and contraction in the three multicellular eukaryotes. This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement.
Original languageEnglish
Pages (from-to)796-815
Publication statusPublished - 2000

Fingerprint Dive into the research topics of 'Analysis of the genome sequence of the flowering plant Arabidopsis thaliana'. Together they form a unique fingerprint.

  • Cite this

    Kaul, S., Koo, H. L., Jenkins, J., Rizzo, M., Rooney, T., Tallon, L. J., ... Stiekema, W. J. (2000). Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature, 408, 796-815.