Analysis of Natural and Engineered Amyloid Aggregates by Spectroscopic and Scattering Techniques

T.R. Heyn, V.M. Garamus*, Anja Steffen-Heins, K. Schwarz, J.K. Keppler

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

Abstract

The increasing knowledge about natural functional fibrils has triggered the interest in synthetic or engineered fibrils. Naturally occurring amyloid fibrils (functional and pathogenic) have been analyzed for many years at different structural levels. Engineered fibrils are structurally similar to natural fibrils and the main sub-structural feature of amyloids is characterized by cross-beta structure stabilizing the fibril formation. However, a number of peculiarities exist comparing natural and engineered fibrils that may affect their analysis, especially in spectroscopic and scattering methods. For this reason, several methods that are commonly used for natural fibril analysis are presented and particularities for their application in the characterization of engineered fibrils are described. In addition, the understanding about structure–function relation of fibrils studied in the different research areas may mutually improve when using the same analytical approaches for natural and engineered fibrils

Original languageEnglish
Title of host publicationSoft Matter Systems for Biomedical Applications
EditorsLeonid Bulavin, Nikolai Lebovka
PublisherSpringer Science and Business Media Deutschland GmbH
Pages295-314
Number of pages20
ISBN (Electronic)9783030809249
ISBN (Print)9783030809232
DOIs
Publication statusPublished - 2022
Event9th International Conference on Physics of Liquid Matter: Modern Problems, PLMMP 2020 - Kyiv, Ukraine
Duration: 22 May 202026 May 2020

Publication series

NameSpringer Proceedings in Physics
Volume266
ISSN (Print)0930-8989
ISSN (Electronic)1867-4941

Conference

Conference9th International Conference on Physics of Liquid Matter: Modern Problems, PLMMP 2020
CountryUkraine
CityKyiv
Period22/05/2026/05/20

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