@inproceedings{2783cc72d5504e0f972722f49a5b129b,
title = "Analysis of Natural and Engineered Amyloid Aggregates by Spectroscopic and Scattering Techniques",
abstract = "The increasing knowledge about natural functional fibrils has triggered the interest in synthetic or engineered fibrils. Naturally occurring amyloid fibrils (functional and pathogenic) have been analyzed for many years at different structural levels. Engineered fibrils are structurally similar to natural fibrils and the main sub-structural feature of amyloids is characterized by cross-beta structure stabilizing the fibril formation. However, a number of peculiarities exist comparing natural and engineered fibrils that may affect their analysis, especially in spectroscopic and scattering methods. For this reason, several methods that are commonly used for natural fibril analysis are presented and particularities for their application in the characterization of engineered fibrils are described. In addition, the understanding about structure–function relation of fibrils studied in the different research areas may mutually improve when using the same analytical approaches for natural and engineered fibrils",
author = "T.R. Heyn and V.M. Garamus and Anja Steffen-Heins and K. Schwarz and J.K. Keppler",
year = "2022",
doi = "10.1007/978-3-030-80924-9_11",
language = "English",
isbn = "9783030809232",
series = "Springer Proceedings in Physics",
publisher = "Springer",
pages = "295--314",
editor = "Leonid Bulavin and Nikolai Lebovka",
booktitle = "Soft Matter Systems for Biomedical Applications",
address = "Germany",
note = "9th International Conference on Physics of Liquid Matter: Modern Problems, PLMMP 2020 ; Conference date: 22-05-2020 Through 26-05-2020",
}