Analysis of highly polar pesticides and their main metabolites in animal origin matrices by hydrophilic interaction liquid chromatography and mass spectrometry

Sonia Herrera López*, Jonatan Dias, André de Kok

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)

    Abstract

    In this work, a method for the analysis of 14 highly polar pesticides in animal origin matrices by hydrophilic interaction liquid chromatography and mass spectrometry has been described. Three methanol-based extraction procedures with slight modifications, depending on the matrix, have been used. The method has been validated according to the performance criteria from the SANTE guideline for pesticide residues analysis in food and feed. Most of the compounds showed a limit of quantitation at the lowest spike levels tested (0.01–0.02 mg kg−1) in the matrices evaluated. A SPE clean-up step with mixed mode cation exchange sorbent has been used with some matrices, like chicken meat, eggs, liver and kidney, in order to improve the limits of quantification. Glufosinate, glyphosate and HEPA were the compounds which presented more difficulties during the study, due to the lack of sensitivity of the qualifier ions and/or because of the interference from the matrices.

    Original languageEnglish
    Article number107289
    JournalFood Control
    Volume115
    DOIs
    Publication statusPublished - Sep 2020

    Keywords

    • Animal origin matrices
    • Glyphosate
    • Hydrophilic interaction liquid chromatography
    • Isotopically labelled internal standards
    • Polar pesticides

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