Analysis and dissipation of the antiparasitic agent ivermectin in cattle dung under different field conditions

Manuel Wohde*, Wolf U. Blanckenhorn, Kevin D. Floate, Joost Lahr, Jean Pierre Lumaret, Jörg Römbke, Adam Scheffczyk, Thomas Tixier, Rolf Alexander Düring

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)


Cattle treated with the veterinary parasiticide ivermectin fecally excrete residues. The authors report the exposition and dissipation characteristics of these residues in dung of ivermectin-treated cattle and in soil beneath this dung on pastures in Canada, France, Switzerland, and The Netherlands. Residues were quantified for dung collected from cattle after 3d, 7d, 14d, and 28d posttreatment and subsequently exposed in the field for up to 13mo. The authors optimized a high-performance liquid chromatography-fluorescence detection method to detect ivermectin residues in dung and soil matrices. They showed that a solid phase extraction and purification step generally can be eliminated to reduce the time and cost of these analyses. They also found that the addition of water to relatively dry samples improves the extraction efficiency of residues. They then analyzed the field samples to document differences in ivermectin dissipation in cattle dung among sites, with 50% dissipation times of up to 32d and 90% dissipation times >396d. They further showed that the dissipation characteristics of residues are comparable between dung of ivermectin-treated cattle and dung to which ivermectin has been added directly. Lastly, they report the first use of a desorption electrospray ionization-high-resolution-mass spectrometric method to detect residues of metabolites in a dung matrix

Original languageEnglish
Pages (from-to)1924-1933
JournalEnvironmental Toxicology and Chemistry
Issue number8
Publication statusPublished - 2016


  • Cattle dung
  • Environmental chemistry
  • Fate and transport
  • Ivermectin
  • Pharmaceutical

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