Salinisation can have different adverse impacts on water resources that are used for drinking, irrigation, or industrial purposes. In addition, salinisation in its turn is also strongly influenced by anthropogenic activities such as irrigation. This paper maps trade-offs between water quality (SDG 6.3) and other Sustainable Development Goals (SDGs) using salinisation as an example. Many interlinkages exist between SDG 6.3 and other SDGs as identified in the literature review part. These are however not yet fully addressed in studies applying a comprehensive systems approach or modelling frameworks. In order to find solution options for achieving a sustainable future the interlinkages between SDGs related to salinisation and its impacts need to be considered as they play a key role in mitigating impacts, prioritising measures for action and hence turning trade-offs into synergies.