An Outlook on the Localisation and Structure-Function Relationships of R Proteins in Solanum

E.J. Slootweg, W.I.L. Tameling, J. Roosien, P. Lukasik, M. Joosten, F. Takken, J. Bakker, A. Goverse

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3 Citations (Scopus)


The co-evolution of plants and plant-pathogens shaped a multi-layered defence system in plants, in which Resistance proteins (R proteins) play a significant role. A fundamental understanding of the functioning of these R proteins and their position in the broader defence system of the plant is essential. Sub-project 3 of the BIOEXPLOIT programme studies how R proteins are activated upon effector recognition and how recognition is conveyed in resistance signalling pathways, using the solanaceous R proteins Rx1 (from S. tuberosum spp. andigena; conferring extreme resistance against Potato Virus X), I-2 (from S. lycopersicon; mediating resistance to Fusarium oxysporum) and Mi-1.2 (from S. lycopersicon; conferring resistance to Meloidogyne incognita) as model systems. The results obtained in this project will serve as a model for other R proteins and will be translated to potential applications or alternative strategies for disease resistance. These include the modification of the recognition specificity of R proteins with the aim to obtain broad spectrum resistance to major pathogens in potato.
Original languageEnglish
Pages (from-to)229-235
JournalPotato Research
Issue number3
Publication statusPublished - 2009


  • Co-evolution
  • Elicitors
  • Nematodes
  • Potato
  • Potato virus
  • R proteins
  • Resistance breeding
  • Solanum


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