An intragenic distribution bias of DNA uptake sequences in Pasteurellaceae and Neisseriae

M.W.J. van Passel

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Most sequenced strains from Pasteurellaceae and Neisseriae contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence for DNA uptake. The mechanism of their recognition is still unclear, and I searched for intragenic location patterns of these motifs for clues about their distribution. In all cases, one orientation of the US has a higher occurrence in the reading frame, and in all Pasteurellaceae, the US and the reverse complement motifs are biased towards the gene termini. These findings could help design experimental set-ups to study preferential DNA uptake, thereby further unravelling the phenomenon of natural competence
Original languageEnglish
Article number12
JournalBiology Direct
Volume3
DOIs
Publication statusPublished - 2008

Keywords

  • uptake signal sequences
  • lateral gene-transfer
  • hemophilus transformation
  • genome
  • specificity
  • influenzae
  • evolution

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