An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis

N. Willemse, K.J. Howell, L.A. Weinert, A. Heuvelink, Y. Pannekoek, J.A. Wagenaar, H.E. Smith, A. Van Der Ende, C. Schultsz

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Abstract

Streptococcus suis is a zoonotic swine pathogen and a major public health concern in Asia, where it emerged as an important cause of bacterial meningitis in adults. While associated with food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsewhere. To identify genomic differences that can explain zoonotic potential, we compared whole genomes of 98 S. suis isolates from human patients and pigs with invasive disease in the Netherlands, and validated our observations with 18 complete and publicly available sequences. Zoonotic isolates have smaller genomes than non-zoonotic isolates, but contain more virulence factors. We identified a zoonotic S. suis clone that diverged from a non-zoonotic clone by means of gene loss, a capsule switch, and acquisition of a two-component signalling system in the late 19th century, when foreign pig breeds were introduced. Our results indicate that zoonotic potential of S. suis results from gene loss, recombination and horizontal gene transfer events.

Original languageEnglish
Article number28984
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016

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Streptococcus suis
Zoonoses
Netherlands
Virulence
Clone Cells
Swine
Genome
Horizontal Gene Transfer
Bacterial Meningitides
Virulence Factors
Genetic Recombination
Genes
Capsules
Public Health
Food
Infection

Cite this

Willemse, N., Howell, K. J., Weinert, L. A., Heuvelink, A., Pannekoek, Y., Wagenaar, J. A., ... Schultsz, C. (2016). An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis. Scientific Reports, 6, [28984]. https://doi.org/10.1038/srep28984
Willemse, N. ; Howell, K.J. ; Weinert, L.A. ; Heuvelink, A. ; Pannekoek, Y. ; Wagenaar, J.A. ; Smith, H.E. ; Van Der Ende, A. ; Schultsz, C. / An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis. In: Scientific Reports. 2016 ; Vol. 6.
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abstract = "Streptococcus suis is a zoonotic swine pathogen and a major public health concern in Asia, where it emerged as an important cause of bacterial meningitis in adults. While associated with food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsewhere. To identify genomic differences that can explain zoonotic potential, we compared whole genomes of 98 S. suis isolates from human patients and pigs with invasive disease in the Netherlands, and validated our observations with 18 complete and publicly available sequences. Zoonotic isolates have smaller genomes than non-zoonotic isolates, but contain more virulence factors. We identified a zoonotic S. suis clone that diverged from a non-zoonotic clone by means of gene loss, a capsule switch, and acquisition of a two-component signalling system in the late 19th century, when foreign pig breeds were introduced. Our results indicate that zoonotic potential of S. suis results from gene loss, recombination and horizontal gene transfer events.",
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Willemse, N, Howell, KJ, Weinert, LA, Heuvelink, A, Pannekoek, Y, Wagenaar, JA, Smith, HE, Van Der Ende, A & Schultsz, C 2016, 'An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis' Scientific Reports, vol. 6, 28984. https://doi.org/10.1038/srep28984

An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis. / Willemse, N.; Howell, K.J.; Weinert, L.A.; Heuvelink, A.; Pannekoek, Y.; Wagenaar, J.A.; Smith, H.E.; Van Der Ende, A.; Schultsz, C.

In: Scientific Reports, Vol. 6, 28984, 2016.

Research output: Contribution to journalArticleAcademicpeer-review

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