@inproceedings{aa2c4d7ad4914befb0c713369ee9321b,
title = "An automated modular microsystem for enzymatic digestion with gut-on-a-chip applications",
abstract = "Gut-on-a-chip models have gained attention as replacements for other cell-based assays or animal studies in drug development or toxicological studies. These models aim to provide a more accurate representation of the in vivo situation in form and function; however, no digestive processes have been included in these systems so far. This work describes a miniaturized digestive system based on artificial digestive juices that digest liquid samples in a series of three microreactors. After optimization of the pH value of juices and mixtures, samples leading to fluorescent products were digested to demonstrate enzyme functionality and to determine kinetic parameters.",
keywords = "Digestion, Enzyme kinetics, Gut-on-a-chip, Organ-on-a-chip",
author = "{de Haan}, P. and M.A. Ianovska and K. Mathwig and H. Bouwmeester and E. Verpoorte",
year = "2020",
language = "English",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1593--1594",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
}