AMUC-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status

Willem Meindert De Vos; Hanne Lore Paula Tytgat; Daniël Christianus Swarts

AMUC-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status

Willem Meindert De Vos (Inventor), Hanne Lore Paula Tytgat (Inventor), Daniël Christianus Swarts (Inventor)

Research output: Patent

Abstract

Polypeptide variants of an extracellular polypeptide of Akkermansia municiphila are provided which are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.

Original language	English
Patent number	WO2022002660
Priority date	1/07/20
Publication status	Published - 6 Jan 2022

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title = "AMUC-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status",

abstract = "Polypeptide variants of an extracellular polypeptide of Akkermansia municiphila are provided which are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.",

author = "\{De Vos\}, \{Willem Meindert\} and Tytgat, \{Hanne Lore Paula\} and Swarts, \{Dani{\"e}l Christianus\}",

year = "2022",

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day = "6",

language = "English",

type = "Patent",

note = "WO2022002660",

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T1 - AMUC-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status

AU - De Vos, Willem Meindert

AU - Tytgat, Hanne Lore Paula

AU - Swarts, Daniël Christianus

PY - 2022/1/6

Y1 - 2022/1/6

N2 - Polypeptide variants of an extracellular polypeptide of Akkermansia municiphila are provided which are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.

AB - Polypeptide variants of an extracellular polypeptide of Akkermansia municiphila are provided which are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.

M3 - Patent

M1 - WO2022002660

ER -

AMUC-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status

Abstract

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