Amsacta moorei entomopoxvirus encodes a functional DNA photolyase (AMV025)

R. Nalcacioglu, Y.A. Dizman, J.M. Vlak, Z. Demirbag, M.M. van Oers

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

The major damage induced in DNA by ultraviolet light is the induction of cyclobutane pyrimidine dimers (CPDs). Amsacta moorei entomopoxvirus (AMEV) encodes a CPD photolyase (AMV025) with a putative role in converting these dimers back into monomers. In infected Lymantria dispar cells transcription of the AMV025 gene started 8 h post inoculation (p.i.) and continued through 38 h p.i. Transcription was inhibited by a DNA synthesis blocker. Transient expression in an Escherichia coil strain that lacks its endogenous photolyase, rescued growth of the UV-irradiated bacteria in a light-dependent manner, showing that AMV025 encodes a functional DNA photolyase
Original languageEnglish
Pages (from-to)363-365
JournalJournal of Invertebrate Pathology
Volume105
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • chrysodeixis-chalcites
  • fowlpox virus
  • genome sequence
  • cpd-photolyase
  • repair enzyme
  • baculovirus
  • gene
  • nucleopolyhedrovirus
  • identification
  • cryptochromes

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