Alternative coenzymes for biocatalysis

Alice Guarneri, Willem J.H. van Berkel, Caroline E. Paul*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.

Original languageEnglish
Pages (from-to)63-71
JournalCurrent Opinion in Biotechnology
Volume60
DOIs
Publication statusPublished - Dec 2019

Fingerprint

Biocatalysis
Coenzymes
Enzymes
Flavins
Chemical reactivity
Niacinamide
Reaction rates
Costs and Cost Analysis
Molecules
Costs

Cite this

@article{aca0cd66c065455292c89d800ef1afcc,
title = "Alternative coenzymes for biocatalysis",
abstract = "Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.",
author = "Alice Guarneri and {van Berkel}, {Willem J.H.} and Paul, {Caroline E.}",
year = "2019",
month = "12",
doi = "10.1016/j.copbio.2019.01.001",
language = "English",
volume = "60",
pages = "63--71",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier",

}

Alternative coenzymes for biocatalysis. / Guarneri, Alice; van Berkel, Willem J.H.; Paul, Caroline E.

In: Current Opinion in Biotechnology, Vol. 60, 12.2019, p. 63-71.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Alternative coenzymes for biocatalysis

AU - Guarneri, Alice

AU - van Berkel, Willem J.H.

AU - Paul, Caroline E.

PY - 2019/12

Y1 - 2019/12

N2 - Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.

AB - Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.

U2 - 10.1016/j.copbio.2019.01.001

DO - 10.1016/j.copbio.2019.01.001

M3 - Article

VL - 60

SP - 63

EP - 71

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

ER -