Abstract
Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.
| Language | English |
|---|---|
| Pages | 63-71 |
| Journal | Current Opinion in Biotechnology |
| Volume | 60 |
| DOIs | |
| Publication status | Published - Dec 2019 |
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Alternative coenzymes for biocatalysis. / Guarneri, Alice; van Berkel, Willem J.H.; Paul, Caroline E.
In: Current Opinion in Biotechnology, Vol. 60, 12.2019, p. 63-71.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Alternative coenzymes for biocatalysis
AU - Guarneri, Alice
AU - van Berkel, Willem J.H.
AU - Paul, Caroline E.
PY - 2019/12
Y1 - 2019/12
N2 - Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.
AB - Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several coenzymes, nicotinamides and flavins, have been known for close to a century, whereas variations of those organic molecules have more recently come to light. In general, the requirement of these coenzymes imposes certain constraints for in vitro enzyme use in biocatalytic processes. Alternative coenzymes have risen to circumvent the cost factor, tune reaction rates or obtain different chemical reactivity. This review will focus on these alternatives and their role and applications in biocatalysis.
U2 - 10.1016/j.copbio.2019.01.001
DO - 10.1016/j.copbio.2019.01.001
M3 - Review article
VL - 60
SP - 63
EP - 71
JO - Current Opinion in Biotechnology
T2 - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
ER -