Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics

R. Hummelen, A.P. Vos, B. van 't Land, K. van Norren, G. Reid

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Abstract

The intestinal immune system is severely affected by HIV and circulating microbial products from the intestinal tract that provide an ongoing source of systemic inflammation and concomitant viral replication. In addition, HIV-infected individuals can have a deregulated immune response that may hamper the anti-viral capacity of the host. Various probiotic organisms and prebiotic agents have been shown to enhance intestinal epithelial barrier functions, reduce inflammation, and support effective Th-1 responses. As these characteristics may benefit HIV patients, this review aims to provide a theoretical framework for the development of probiotic and prebiotic interventions specifically for this population.
Original languageEnglish
Pages (from-to)485-513
JournalInternational Reviews of Immunology
Volume29
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • human-immunodeficiency-virus
  • randomized controlled-trial
  • placebo-controlled trial
  • coli nissle 1917
  • chain galacto-oligosaccharides
  • active antiretroviral therapy
  • inflammatory bowel diseases
  • intestinal epithelial-cells
  • lactobacillus-rhamnosus-gg
  • ele

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