Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

M.M. Joosten, R.F. Witkamp, H.F.J. Hendriks

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17 Citations (Scopus)

Abstract

Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high–molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin. In a randomized, crossover trial, 24 premenopausal women who were regular alcohol consumers received beer (~26 g alcohol) or alcohol-free beer daily for 3 weeks preceded by a 1-week washout. Blood samples were collected weekly after an overnight fast for measurement of total and HMW adiponectin and markers of glucose and lipid metabolism. There was a significant interaction (P <.05) between the 2 treatments over time for both plasma HMW and total adiponectin concentrations. Within 3 weeks, plasma total (8.2%, P = .01) and HMW (8.2%, P = .02) adiponectin levels were higher after moderate alcohol consumption compared with abstention. Changes over time in total adiponectin were positively associated with changes in HMW adiponectin during the nonalcoholic beer (r = 0.80; 95% confidence interval, 0.55-0.92) and beer (r = 0.82; 0.58-0.93) intervention. Alcohol consumption did not affect the ratio of HMW to total adiponectin or the serum glucose, insulin, hemoglobin A1c, or triglyceride levels compared with abstention during the intervention periods. Both total and HMW adiponectin concentrations are higher after moderate alcohol consumption compared with abstention in premenopausal women. These effects were evident after at least 3 weeks of consumption and occurred concomitantly
Original languageEnglish
Pages (from-to)1058-1063
JournalMetabolism : Clinical and Experimental
Volume60
Issue number8
DOIs
Publication statusPublished - 2011

Fingerprint

Adiponectin
Alcohol Drinking
Molecular Weight
Weights and Measures
Alcohols
Glucose
Lipid Metabolism
Cross-Over Studies
Hemoglobins
Triglycerides
Confidence Intervals
Insulin

Keywords

  • type-2 diabetes-mellitus
  • randomized controlled-trial
  • necrosis-factor-alpha
  • insulin sensitivity
  • postmenopausal women
  • metabolic syndrome
  • red wine
  • myocardial-infarction
  • glucose-metabolism
  • hdl-cholesterol

Cite this

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title = "Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women",
abstract = "Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high–molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin. In a randomized, crossover trial, 24 premenopausal women who were regular alcohol consumers received beer (~26 g alcohol) or alcohol-free beer daily for 3 weeks preceded by a 1-week washout. Blood samples were collected weekly after an overnight fast for measurement of total and HMW adiponectin and markers of glucose and lipid metabolism. There was a significant interaction (P <.05) between the 2 treatments over time for both plasma HMW and total adiponectin concentrations. Within 3 weeks, plasma total (8.2{\%}, P = .01) and HMW (8.2{\%}, P = .02) adiponectin levels were higher after moderate alcohol consumption compared with abstention. Changes over time in total adiponectin were positively associated with changes in HMW adiponectin during the nonalcoholic beer (r = 0.80; 95{\%} confidence interval, 0.55-0.92) and beer (r = 0.82; 0.58-0.93) intervention. Alcohol consumption did not affect the ratio of HMW to total adiponectin or the serum glucose, insulin, hemoglobin A1c, or triglyceride levels compared with abstention during the intervention periods. Both total and HMW adiponectin concentrations are higher after moderate alcohol consumption compared with abstention in premenopausal women. These effects were evident after at least 3 weeks of consumption and occurred concomitantly",
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Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women. / Joosten, M.M.; Witkamp, R.F.; Hendriks, H.F.J.

In: Metabolism : Clinical and Experimental, Vol. 60, No. 8, 2011, p. 1058-1063.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

AU - Joosten, M.M.

AU - Witkamp, R.F.

AU - Hendriks, H.F.J.

PY - 2011

Y1 - 2011

N2 - Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high–molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin. In a randomized, crossover trial, 24 premenopausal women who were regular alcohol consumers received beer (~26 g alcohol) or alcohol-free beer daily for 3 weeks preceded by a 1-week washout. Blood samples were collected weekly after an overnight fast for measurement of total and HMW adiponectin and markers of glucose and lipid metabolism. There was a significant interaction (P <.05) between the 2 treatments over time for both plasma HMW and total adiponectin concentrations. Within 3 weeks, plasma total (8.2%, P = .01) and HMW (8.2%, P = .02) adiponectin levels were higher after moderate alcohol consumption compared with abstention. Changes over time in total adiponectin were positively associated with changes in HMW adiponectin during the nonalcoholic beer (r = 0.80; 95% confidence interval, 0.55-0.92) and beer (r = 0.82; 0.58-0.93) intervention. Alcohol consumption did not affect the ratio of HMW to total adiponectin or the serum glucose, insulin, hemoglobin A1c, or triglyceride levels compared with abstention during the intervention periods. Both total and HMW adiponectin concentrations are higher after moderate alcohol consumption compared with abstention in premenopausal women. These effects were evident after at least 3 weeks of consumption and occurred concomitantly

AB - Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high–molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin. In a randomized, crossover trial, 24 premenopausal women who were regular alcohol consumers received beer (~26 g alcohol) or alcohol-free beer daily for 3 weeks preceded by a 1-week washout. Blood samples were collected weekly after an overnight fast for measurement of total and HMW adiponectin and markers of glucose and lipid metabolism. There was a significant interaction (P <.05) between the 2 treatments over time for both plasma HMW and total adiponectin concentrations. Within 3 weeks, plasma total (8.2%, P = .01) and HMW (8.2%, P = .02) adiponectin levels were higher after moderate alcohol consumption compared with abstention. Changes over time in total adiponectin were positively associated with changes in HMW adiponectin during the nonalcoholic beer (r = 0.80; 95% confidence interval, 0.55-0.92) and beer (r = 0.82; 0.58-0.93) intervention. Alcohol consumption did not affect the ratio of HMW to total adiponectin or the serum glucose, insulin, hemoglobin A1c, or triglyceride levels compared with abstention during the intervention periods. Both total and HMW adiponectin concentrations are higher after moderate alcohol consumption compared with abstention in premenopausal women. These effects were evident after at least 3 weeks of consumption and occurred concomitantly

KW - type-2 diabetes-mellitus

KW - randomized controlled-trial

KW - necrosis-factor-alpha

KW - insulin sensitivity

KW - postmenopausal women

KW - metabolic syndrome

KW - red wine

KW - myocardial-infarction

KW - glucose-metabolism

KW - hdl-cholesterol

U2 - 10.1016/j.metabol.2011.01.001

DO - 10.1016/j.metabol.2011.01.001

M3 - Article

VL - 60

SP - 1058

EP - 1063

JO - Metabolism : Clinical and Experimental

JF - Metabolism : Clinical and Experimental

SN - 0026-0495

IS - 8

ER -