Allorecognition genes drive reproductive isolation in Podospora anserina

S.L. Ament-Velásquez*, Aaron A. Vogan, Alexandra Granger-Farbos, Eric Bastiaans, Ivain Martinossi-Allibert, Sven J. Saupe, Suzette de Groot, Martin Lascoux, Alfons J.M. Debets, Corinne Clavé, Hanna Johannesson

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Allorecognition, the capacity to discriminate self from conspecific non-self, is a ubiquitous organismal feature typically governed by genes evolving under balancing selection. Here, we show that in the fungus Podospora anserina, allorecognition loci controlling vegetative incompatibility (het genes), define two reproductively isolated groups through pleiotropic effects on sexual compatibility. These two groups emerge from the antagonistic interactions of the unlinked loci het-r (encoding a NOD-like receptor) and het-v (encoding a methyltransferase and an MLKL/HeLo domain protein). Using a combination of genetic and ecological data, supported by simulations, we provide a concrete and molecularly defined example whereby the origin and coexistence of reproductively isolated groups in sympatry is driven by pleiotropic genes under balancing selection.
Original languageEnglish
Pages (from-to)910-923
JournalNature Ecology and Evolution
Volume6
Issue number7
Early online date12 May 2022
DOIs
Publication statusPublished - Jul 2022

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