Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines

C.A. Sevillano; B. Harlizius; M.F.L. Derks; M.S. Lopes; M. van Son; E.F. Knol

doi:10.3920/978-90-8686-940-4_451

Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines

C.A. Sevillano, B. Harlizius, M.F.L. Derks, M.S. Lopes, M. van Son, E.F. Knol

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

Abstract

Several QTL regions affecting number of teats have been detected in commercial pig lines. In this study we follow the indirect effects of index selection on different QTL regions for number of teats in two maternal lines in 40K animals with imputed 555K SNP. In total, 3 QTL regions overlap between the two populations. For a QTL on Sus scrofa chromosome 7 (SSC7), the underlying functional variation affecting number of thoracic vertebrae located in the vertnin gene has also been genotyped showing an allelic substitution effect of nearly 0.4 teats in both lines. However, allele frequencies show an opposite trend at the vertnin gene locus in the two lines. Moreover, epistatic effects between two QTL regions on SSC7 and SSC12 are investigated at the molecular and phenotypic level.

Original language	English
Title of host publication	Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publication	Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
Editors	R.F. Veerkamp, Y. de Haas
Place of Publication	Wageningen
Publisher	Wageningen Academic Publishers
Pages	1876-1879
ISBN (Electronic)	9789086869404
DOIs	https://doi.org/10.3920/978-90-8686-940-4_451
Publication status	Published - 2022
Event	World Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands Duration: 3 Jul 2022 → 8 Jul 2022

Conference

Conference	World Congress on Genetics Applied to Livestock Production: WCGALP 2022
Country/Territory	Netherlands
City	Rotterdam
Period	3/07/22 → 8/07/22

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https://edepot.wur.nl/588168Licence: CC BY

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Sevillano, C. A., Harlizius, B., Derks, M. F. L., Lopes, M. S., van Son, M., & Knol, E. F. (2022). Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines. In R. F. Veerkamp, & Y. de Haas (Eds.), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges (pp. 1876-1879). Article 451 Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-940-4_451

Sevillano, C.A. ; Harlizius, B. ; Derks, M.F.L. et al. / Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines. Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. editor / R.F. Veerkamp ; Y. de Haas. Wageningen : Wageningen Academic Publishers, 2022. pp. 1876-1879

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title = "Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines",

abstract = "Several QTL regions affecting number of teats have been detected in commercial pig lines. In this study we follow the indirect effects of index selection on different QTL regions for number of teats in two maternal lines in 40K animals with imputed 555K SNP. In total, 3 QTL regions overlap between the two populations. For a QTL on Sus scrofa chromosome 7 (SSC7), the underlying functional variation affecting number of thoracic vertebrae located in the vertnin gene has also been genotyped showing an allelic substitution effect of nearly 0.4 teats in both lines. However, allele frequencies show an opposite trend at the vertnin gene locus in the two lines. Moreover, epistatic effects between two QTL regions on SSC7 and SSC12 are investigated at the molecular and phenotypic level.",

author = "C.A. Sevillano and B. Harlizius and M.F.L. Derks and M.S. Lopes and {van Son}, M. and E.F. Knol",

year = "2022",

doi = "10.3920/978-90-8686-940-4_451",

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Sevillano, CA, Harlizius, B, Derks, MFL, Lopes, MS, van Son, M & Knol, EF 2022, Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines. in RF Veerkamp & Y de Haas (eds), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges., 451, Wageningen Academic Publishers, Wageningen, pp. 1876-1879, World Congress on Genetics Applied to Livestock Production: WCGALP 2022, Rotterdam, Netherlands, 3/07/22. https://doi.org/10.3920/978-90-8686-940-4_451

Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines. / Sevillano, C.A.; Harlizius, B.; Derks, M.F.L. et al.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. ed. / R.F. Veerkamp; Y. de Haas. Wageningen: Wageningen Academic Publishers, 2022. p. 1876-1879 451.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

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T1 - Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines

AU - Sevillano, C.A.

AU - Harlizius, B.

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AU - Lopes, M.S.

AU - van Son, M.

AU - Knol, E.F.

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Y1 - 2022

N2 - Several QTL regions affecting number of teats have been detected in commercial pig lines. In this study we follow the indirect effects of index selection on different QTL regions for number of teats in two maternal lines in 40K animals with imputed 555K SNP. In total, 3 QTL regions overlap between the two populations. For a QTL on Sus scrofa chromosome 7 (SSC7), the underlying functional variation affecting number of thoracic vertebrae located in the vertnin gene has also been genotyped showing an allelic substitution effect of nearly 0.4 teats in both lines. However, allele frequencies show an opposite trend at the vertnin gene locus in the two lines. Moreover, epistatic effects between two QTL regions on SSC7 and SSC12 are investigated at the molecular and phenotypic level.

AB - Several QTL regions affecting number of teats have been detected in commercial pig lines. In this study we follow the indirect effects of index selection on different QTL regions for number of teats in two maternal lines in 40K animals with imputed 555K SNP. In total, 3 QTL regions overlap between the two populations. For a QTL on Sus scrofa chromosome 7 (SSC7), the underlying functional variation affecting number of thoracic vertebrae located in the vertnin gene has also been genotyped showing an allelic substitution effect of nearly 0.4 teats in both lines. However, allele frequencies show an opposite trend at the vertnin gene locus in the two lines. Moreover, epistatic effects between two QTL regions on SSC7 and SSC12 are investigated at the molecular and phenotypic level.

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BT - Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)

A2 - Veerkamp, R.F.

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PB - Wageningen Academic Publishers

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Sevillano CA, Harlizius B, Derks MFL, Lopes MS, van Son M, Knol EF. Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines. In Veerkamp RF, de Haas Y, editors, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers. 2022. p. 1876-1879. 451 doi: 10.3920/978-90-8686-940-4_451

Allele frequency differences at epistatic QTL explain different genetic trends in number of teats in two pig lines

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