All-cause mortality rates in patients with type 1 diabetes mellitus compared to a non-diabetic population from the General Practice Research Database (GPRD), 1992-1999

S.S. Soedamah-Muthu, J.H. Fuller, H.E. Mulnier, V.S. Raleigh, R.A. Lawrenson, H.M. Colhoun

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Abstract

AIMS/HYPOTHESIS: We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. MATERIALS AND METHODS: We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. RESULTS: The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p
Original languageEnglish
Pages (from-to)660-666
JournalDiabetologia
Volume49
Issue number4
DOIs
Publication statusPublished - 2006

Keywords

  • term mortality
  • united-kingdom
  • follow-up
  • diagnosis
  • disease
  • cohort
  • onset

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