Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size. The EPIC-InterAct study

A. The InterAct Consortium, E.J.M. Feskens

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Abstract

Objective: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. Design: Multicentre prospective case–cohort study. Setting: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. Subjects: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes. Interventions: Alcohol consumption assessed using validated dietary questionnaires. Main outcome measures: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information. Results: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.78–1.05) for 6.1–12.0 versus 0.1–6.0 g day-1, adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.1–96.0 g day-1 with an HR of 0.86 (95% CI: 0.75–0.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.72–0.92) for 6.1–12.0 g day-1 (P interaction gender
Original languageEnglish
Pages (from-to)358-370
JournalJournal of Internal Medicine
Volume272
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • randomized controlled-trial
  • insulin sensitivity
  • postmenopausal women
  • drinking patterns
  • physical-activity
  • dietary-intake
  • older women
  • cancer
  • cohort
  • intervention

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