Alcohol consumption and risk of cardiovascular disease and type 2 diabetes : population-based studies and physiological interventions = Alcoholconsumptie en risico op cardiovasculaire ziekten en type 2 diabetes : populatiestudies en fysiologische interventies

J.W.J. Beulens

Research output: Thesisinternal PhD, WU

Abstract

Research described in this thesis provides evidence for a causal inverse relation of moderate alcohol consumption with cardiovascular disease and type 2 diabetes. First, it showed that these inverse associations are consistent over different populations such as hypertensive men and older women, both at increased risk of those diseases. Increased cholesterol efflux and adiponectin concentrations after moderate alcohol consumption are a plausible mechanism to explain the associations. Finally, an interaction of alcohol intake with the alcohol dehydrogenase gene for type 2 diabetes indicates that this relation may be causal and due to downstream metabolites instead of ethanol itself.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Schaafsma, G., Promotor
  • Kok, Frans, Promotor
  • Hendriks, H.F.J., Co-promotor, External person
Award date17 Jan 2007
Place of Publication[S.l.]
Print ISBNs9789085045717
Publication statusPublished - 2007

Keywords

  • alcohol intake
  • cardiovascular diseases
  • diabetes mellitus

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