Akkermansia and microbial degradation of mucus in cats and dogs: Implications to the growing worldwide epidemic of pet obesity

Jose F. Garcia-Mazcorro*, Yasushi Minamoto, Jorge R. Kawas, Jan S. Suchodolski, Willem M. de Vos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Akkermansia muciniphila is a mucin-degrading bacterium that has shown the potential to provide anti-inflammatory and anti-obesity effects in mouse and man. We here focus on companion animals, specifically cats and dogs, and evaluate the microbial degradation of mucus and its health impact in the context of the worldwide epidemic of pet obesity. A literature survey revealed that the two presently known Akkermansia spp., A. muciniphila and A. glycaniphila, as well as other members of the phylum of Verrucomicrobia seem to be neither very prevalent nor abundant in the digestive tract of cats and dog. While this may be due to methodological aspects, it suggests that bacteria related to Akkermansia are not the major mucus degraders in these pets and hence other mucus-utilizing taxa may deserve attention. Hence, we will discuss the potential of these endogenous mucus utilizers and dietary interventions to boost these as well as the use of Akkermansia spp. related bacteria or their components as strategies to target feline and canine obesity.

Original languageEnglish
Article number44
Number of pages25
JournalVeterinary Sciences
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Canine obesity
  • Companion animals
  • Feline obesity
  • Mucus degradation

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