Aggregation of different amino acid conjugates of cholic acid in aqueous solution

H.M. Willemen; T. Vermonden; A. Koudijs; A.T.M. Marcelis; E.J.R. Sudhölter

doi:10.1016/S0927-7757(02)00586-1

Aggregation of different amino acid conjugates of cholic acid in aqueous solution

H.M. Willemen, T. Vermonden, A. Koudijs, A.T.M. Marcelis, E.J.R. Sudhölter

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	59-64
Journal	Colloids and Surfaces. A: Physicochemical and Engineering Aspects
Volume	218
DOIs	https://doi.org/10.1016/S0927-7757(02)00586-1
Publication status	Published - 2003

Keywords

bile-acids
glycine
salts

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10.1016/S0927-7757(02)00586-1

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title = "Aggregation of different amino acid conjugates of cholic acid in aqueous solution",

abstract = "A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.",

keywords = "bile-acids, glycine, salts",

author = "H.M. Willemen and T. Vermonden and A. Koudijs and A.T.M. Marcelis and E.J.R. Sudh{\"o}lter",

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doi = "10.1016/S0927-7757(02)00586-1",

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volume = "218",

pages = "59--64",

journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",

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TY - JOUR

T1 - Aggregation of different amino acid conjugates of cholic acid in aqueous solution

AU - Willemen, H.M.

AU - Vermonden, T.

AU - Koudijs, A.

AU - Marcelis, A.T.M.

AU - Sudhölter, E.J.R.

PY - 2003

Y1 - 2003

N2 - A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.

AB - A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.

KW - bile-acids

KW - glycine

KW - salts

U2 - 10.1016/S0927-7757(02)00586-1

DO - 10.1016/S0927-7757(02)00586-1

M3 - Article

SN - 0927-7757

VL - 218

SP - 59

EP - 64

JO - Colloids and Surfaces. A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces. A: Physicochemical and Engineering Aspects

ER -

Aggregation of different amino acid conjugates of cholic acid in aqueous solution

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Keywords

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