A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.
|Journal||Colloids and Surfaces. A: Physicochemical and Engineering Aspects|
|Publication status||Published - 2003|
Willemen, H. M., Vermonden, T., Koudijs, A., Marcelis, A. T. M., & Sudhölter, E. J. R. (2003). Aggregation of different amino acid conjugates of cholic acid in aqueous solution. Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 218, 59-64. https://doi.org/10.1016/S0927-7757(02)00586-1