Abstract
A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 59-64 |
Journal | Colloids and Surfaces. A: Physicochemical and Engineering Aspects |
Volume | 218 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- bile-acids
- glycine
- salts