Aggregation of different amino acid conjugates of cholic acid in aqueous solution

H.M. Willemen, T. Vermonden, A. Koudijs, A.T.M. Marcelis, E.J.R. Sudhölter

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)


A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)59-64
JournalColloids and Surfaces. A: Physicochemical and Engineering Aspects
Publication statusPublished - 2003


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