Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

Mariona Baliu-Piqué, Henry Kurniawan, Lars Ravesloot, Myrddin W. Verheij, Julia Drylewicz, Karianne Lievaart-Peterson, José A.M. Borghans, Ad Koets, Kiki Tesselaar

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. We characterized the composition of the T-cell pool in neonatal kids and adult goats and quantified their turnover rates using in vivo deuterium labelling. From birth to adulthood, CD4+ T-cells were the predominant subset in the thymus and lymph nodes, while spleen and bone marrow contained mainly CD8+ lymphocytes. In blood, CD4+ T-cells were the predominant subset during the neonatal period, while CD8+ T-cells predominated in adults. We observed that thymic mass and cellularity increased during the first 5 months after birth, but decreased later in life. Deuterium labelling revealed that T-cell turnover rates in neonatal kids are considerably higher than in adult animals.

LanguageEnglish
Pages1-10
JournalDevelopmental and Comparative Immunology
Volume93
DOIs
Publication statusPublished - 1 Apr 2019

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Age Distribution
Lymphoid Tissue
Goats
T-Lymphocytes
Vaccines
Deuterium
Parturition
Paratuberculosis
Disease Susceptibility
Domestic Animals
Thymus Gland
Mammals
Immune System
Spleen
Lymph Nodes
Bone Marrow
Lymphocytes

Keywords

  • Deuterium
  • Development
  • Goat
  • Mathematical modelling
  • Neonatal adaptive immunity
  • Stable isotope labelling
  • T-cell turnover
  • T-lymphocytes

Cite this

Baliu-Piqué, M., Kurniawan, H., Ravesloot, L., Verheij, M. W., Drylewicz, J., Lievaart-Peterson, K., ... Tesselaar, K. (2019). Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats. Developmental and Comparative Immunology, 93, 1-10. https://doi.org/10.1016/j.dci.2018.12.004
Baliu-Piqué, Mariona ; Kurniawan, Henry ; Ravesloot, Lars ; Verheij, Myrddin W. ; Drylewicz, Julia ; Lievaart-Peterson, Karianne ; Borghans, José A.M. ; Koets, Ad ; Tesselaar, Kiki. / Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats. In: Developmental and Comparative Immunology. 2019 ; Vol. 93. pp. 1-10.
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Baliu-Piqué, M, Kurniawan, H, Ravesloot, L, Verheij, MW, Drylewicz, J, Lievaart-Peterson, K, Borghans, JAM, Koets, A & Tesselaar, K 2019, 'Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats', Developmental and Comparative Immunology, vol. 93, pp. 1-10. https://doi.org/10.1016/j.dci.2018.12.004

Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats. / Baliu-Piqué, Mariona; Kurniawan, Henry; Ravesloot, Lars; Verheij, Myrddin W.; Drylewicz, Julia; Lievaart-Peterson, Karianne; Borghans, José A.M.; Koets, Ad; Tesselaar, Kiki.

In: Developmental and Comparative Immunology, Vol. 93, 01.04.2019, p. 1-10.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

AU - Baliu-Piqué, Mariona

AU - Kurniawan, Henry

AU - Ravesloot, Lars

AU - Verheij, Myrddin W.

AU - Drylewicz, Julia

AU - Lievaart-Peterson, Karianne

AU - Borghans, José A.M.

AU - Koets, Ad

AU - Tesselaar, Kiki

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N2 - Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. We characterized the composition of the T-cell pool in neonatal kids and adult goats and quantified their turnover rates using in vivo deuterium labelling. From birth to adulthood, CD4+ T-cells were the predominant subset in the thymus and lymph nodes, while spleen and bone marrow contained mainly CD8+ lymphocytes. In blood, CD4+ T-cells were the predominant subset during the neonatal period, while CD8+ T-cells predominated in adults. We observed that thymic mass and cellularity increased during the first 5 months after birth, but decreased later in life. Deuterium labelling revealed that T-cell turnover rates in neonatal kids are considerably higher than in adult animals.

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KW - Stable isotope labelling

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Baliu-Piqué M, Kurniawan H, Ravesloot L, Verheij MW, Drylewicz J, Lievaart-Peterson K et al. Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats. Developmental and Comparative Immunology. 2019 Apr 1;93:1-10. https://doi.org/10.1016/j.dci.2018.12.004