Age at menopause, reproductive life span, and type 2 diabetes risk results from the EPIC-interAct Study

J.S. Brand, Y.T. van der Schouw, N. Onland-Moret, S.J. Sharp, E.J.M. Feskens

Research output: Contribution to journalArticleAcademicpeer-review

100 Citations (Scopus)

Abstract

OBJECTIVEAge at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODSData were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTSMean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages 0.05).CONCLUSIONSEarly menopause is associated with a greater risk of type 2 diabetes.
Original languageEnglish
Pages (from-to)1012-1019
JournalDiabetes Care
Volume36
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • breast-cancer risk
  • body-size
  • cardiovascular-disease
  • prospective cohort
  • womens health
  • transition
  • reproducibility
  • metaanalysis
  • endometrial
  • nutrition

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