Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human PathogenPseudomonas Aeruginosa

M. Sokovic, A. Ciric, J. Glamoclija, M. Nicolic, L.J.L.D. van Griensven

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Abstract

The edible mushroom Agaricus blazei Murill is known to induce protective immunomodulatory action against a variety of infectious diseases. In the present study we report potential anti-quorum sensing properties of A. blazei hot water extract. Quorum sensing (QS) plays an important role in virulence, biofilm formation and survival of many pathogenic bacteria, including the Gram negative Pseudomonas aeruginosa, and is considered as a novel and promising target for anti-infectious agents. In this study, the effect of the sub-MICs of Agaricus blazei water extract on QS regulated virulence factors and biofilm formation was evaluated against P. aeruginosa PAO1. Sub-MIC concentrations of the extract which did not kill P. aeruginosa nor inhibited its growth, demonstrated a statistically significant reduction of virulence factors of P. aeruginosa, such as pyocyanin production, twitching and swimming motility. The biofilm forming capability of P. aeruginosa was also reduced in a concentration-dependent manner at sub-MIC values. Water extract of A. blazei is a promising source of antiquorum sensing and antibacterial compounds. Keywords: Agaricus blazei; mushroom; antiqourum sensing activity; antimicrobial activity; antibiofilm activity; Pseudomonas aeruginosa.
Original languageEnglish
Pages (from-to)4189-4199
JournalMolecules
Volume19
DOIs
Publication statusPublished - 2014

Fingerprint

Agaricus
Quorum Sensing
Biofilms
Pseudomonas aeruginosa
virulence
biofilms
Virulence Factors
Water
Pyocyanine
pseudomonas
water
twitching
Agaricales
Bacteria
locomotion
infectious diseases
bacteria
Gram-Negative Bacteria
Communicable Diseases
Virulence

Keywords

  • medicinal mushroom
  • biofilm formation
  • inhibition
  • resistance
  • infection
  • virulence
  • impact
  • mice

Cite this

Sokovic, M. ; Ciric, A. ; Glamoclija, J. ; Nicolic, M. ; van Griensven, L.J.L.D. / Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human PathogenPseudomonas Aeruginosa. In: Molecules. 2014 ; Vol. 19. pp. 4189-4199.
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Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human PathogenPseudomonas Aeruginosa. / Sokovic, M.; Ciric, A.; Glamoclija, J.; Nicolic, M.; van Griensven, L.J.L.D.

In: Molecules, Vol. 19, 2014, p. 4189-4199.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Sokovic, M.

AU - Ciric, A.

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AU - van Griensven, L.J.L.D.

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AB - The edible mushroom Agaricus blazei Murill is known to induce protective immunomodulatory action against a variety of infectious diseases. In the present study we report potential anti-quorum sensing properties of A. blazei hot water extract. Quorum sensing (QS) plays an important role in virulence, biofilm formation and survival of many pathogenic bacteria, including the Gram negative Pseudomonas aeruginosa, and is considered as a novel and promising target for anti-infectious agents. In this study, the effect of the sub-MICs of Agaricus blazei water extract on QS regulated virulence factors and biofilm formation was evaluated against P. aeruginosa PAO1. Sub-MIC concentrations of the extract which did not kill P. aeruginosa nor inhibited its growth, demonstrated a statistically significant reduction of virulence factors of P. aeruginosa, such as pyocyanin production, twitching and swimming motility. The biofilm forming capability of P. aeruginosa was also reduced in a concentration-dependent manner at sub-MIC values. Water extract of A. blazei is a promising source of antiquorum sensing and antibacterial compounds. Keywords: Agaricus blazei; mushroom; antiqourum sensing activity; antimicrobial activity; antibiofilm activity; Pseudomonas aeruginosa.

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