Advances and gaps in SARS-CoV-2 infection models

César Munoz-Fontela; Lina Widerspick; Randy A. Albrecht; Martin Beer; Miles W. Carroll; Emmie de Wit; Michael S. Diamond; William E. Dowling; Simon G.P. Funnell; Adolfo Garcia-Sastre; N.M. Gerhards; M.C. Klaassen-de Jong; Vincent J. Munster; Johan Neyts; Stanley Perlman; Douglas S. Reed; Juergen A. Richt; Ximena Riveros-Balta; Chad J. Roy; Francisco J. Salguero; Michael Schotsaert; Lauren M. Schwartz; Robert A. Seder; Joaquim Segalés; Seshadri S. Vasan; Ana Mariá Henao-Restrepo; Dan H. Barouch

doi:10.1371/journal.ppat.1010161

Advances and gaps in SARS-CoV-2 infection models

César Munoz-Fontela, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie de Wit, Michael S. Diamond, William E. Dowling, Simon G.P. Funnell, Adolfo Garcia-Sastre, N.M. Gerhards, M.C. Klaassen-de Jong, Vincent J. Munster, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Ximena Riveros-Balta, Chad J. Roy, Francisco J. SalgueroMichael Schotsaert, Lauren M. Schwartz, Robert A. Seder, Joaquim Segalés, Seshadri S. Vasan, Ana Mariá Henao-Restrepo, Dan H. Barouch^*

^*Corresponding author for this work

Epidemiology, Bio-informatics & Animal models

Research output: Contribution to journal › Article › Academic › peer-review

55 Citations (Scopus)

Abstract

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

Original language	English
Article number	e1010161
Journal	PLoS Pathogens
Volume	18
Issue number	1
DOIs	https://doi.org/10.1371/journal.ppat.1010161
Publication status	Published - 13 Jan 2022

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Munoz-Fontela, C., Widerspick, L., Albrecht, R. A., Beer, M., Carroll, M. W., de Wit, E., Diamond, M. S., Dowling, W. E., Funnell, S. G. P., Garcia-Sastre, A., Gerhards, N. M., Klaassen-de Jong, M. C., Munster, V. J., Neyts, J., Perlman, S., Reed, D. S., Richt, J. A., Riveros-Balta, X., Roy, C. J., ... Barouch, D. H. (2022). Advances and gaps in SARS-CoV-2 infection models. PLoS Pathogens, 18(1), Article e1010161. https://doi.org/10.1371/journal.ppat.1010161

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title = "Advances and gaps in SARS-CoV-2 infection models",

abstract = "The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.",

author = "C{\'e}sar Munoz-Fontela and Lina Widerspick and Albrecht, {Randy A.} and Martin Beer and Carroll, {Miles W.} and {de Wit}, Emmie and Diamond, {Michael S.} and Dowling, {William E.} and Funnell, {Simon G.P.} and Adolfo Garcia-Sastre and N.M. Gerhards and {Klaassen-de Jong}, M.C. and Munster, {Vincent J.} and Johan Neyts and Stanley Perlman and Reed, {Douglas S.} and Richt, {Juergen A.} and Ximena Riveros-Balta and Roy, {Chad J.} and Salguero, {Francisco J.} and Michael Schotsaert and Schwartz, {Lauren M.} and Seder, {Robert A.} and Joaquim Segal{\'e}s and Vasan, {Seshadri S.} and Henao-Restrepo, {Ana Mari{\'a}} and Barouch, {Dan H.}",

year = "2022",

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Munoz-Fontela, C, Widerspick, L, Albrecht, RA, Beer, M, Carroll, MW, de Wit, E, Diamond, MS, Dowling, WE, Funnell, SGP, Garcia-Sastre, A, Gerhards, NM , Klaassen-de Jong, MC, Munster, VJ, Neyts, J, Perlman, S, Reed, DS, Richt, JA, Riveros-Balta, X, Roy, CJ, Salguero, FJ, Schotsaert, M, Schwartz, LM, Seder, RA, Segalés, J, Vasan, SS, Henao-Restrepo, AM & Barouch, DH 2022, 'Advances and gaps in SARS-CoV-2 infection models', PLoS Pathogens, vol. 18, no. 1, e1010161. https://doi.org/10.1371/journal.ppat.1010161

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AU - Munoz-Fontela, César

AU - Widerspick, Lina

AU - Albrecht, Randy A.

AU - Beer, Martin

AU - Carroll, Miles W.

AU - de Wit, Emmie

AU - Diamond, Michael S.

AU - Dowling, William E.

AU - Funnell, Simon G.P.

AU - Garcia-Sastre, Adolfo

AU - Gerhards, N.M.

AU - Klaassen-de Jong, M.C.

AU - Munster, Vincent J.

AU - Neyts, Johan

AU - Perlman, Stanley

AU - Reed, Douglas S.

AU - Richt, Juergen A.

AU - Riveros-Balta, Ximena

AU - Roy, Chad J.

AU - Salguero, Francisco J.

AU - Schotsaert, Michael

AU - Schwartz, Lauren M.

AU - Seder, Robert A.

AU - Segalés, Joaquim

AU - Vasan, Seshadri S.

AU - Henao-Restrepo, Ana Mariá

AU - Barouch, Dan H.

PY - 2022/1/13

Y1 - 2022/1/13

N2 - The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

AB - The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

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DO - 10.1371/journal.ppat.1010161

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VL - 18

JO - PLoS Pathogens

JF - PLoS Pathogens

IS - 1

M1 - e1010161

ER -

Advances and gaps in SARS-CoV-2 infection models

Abstract

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