Advanced aspects of acetogens

Anja Poehlein; Benjamin Zeldes; Maximilian Flaiz; Tim Böer; Alina Lüschen; Franziska Höfele; Kira S. Baur; Bastian Molitor; Christian Kröly; Meng Wang; Quan Zhang; Yixuan Fan; Wei Chao; Rolf Daniel; Fuli Li; Mirko Basen; Volker Müller; Largus T. Angenent; Diana Z. Sousa; Frank R. Bengelsdorf

doi:10.1016/j.biortech.2024.131913

Advanced aspects of acetogens

Anja Poehlein, Benjamin Zeldes, Maximilian Flaiz, Tim Böer, Alina Lüschen, Franziska Höfele, Kira S. Baur, Bastian Molitor, Christian Kröly, Meng Wang, Quan Zhang^*, Yixuan Fan, Wei Chao, Rolf Daniel, Fuli Li, Mirko Basen, Volker Müller, Largus T. Angenent, Diana Z. Sousa, Frank R. Bengelsdorf^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide reduction and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is the Wood-Ljungdahl pathway. This review offers a comprehensive overview of the latest discoveries that are related to acetogens. It delves into a variety of topics, including newly isolated acetogens, their taxonomy and physiology and highlights novel metabolic properties. Additionally, it explores metabolic engineering strategies that are designed to expand the product range of acetogens or to understand specific traits of their metabolism. Lastly, the review presents innovative gas fermentation techniques within the context of industrial applications.

Original language	English
Article number	131913
Journal	Bioresource Technology
Volume	427
DOIs	https://doi.org/10.1016/j.biortech.2024.131913
Publication status	Published - Jul 2025

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Poehlein, A., Zeldes, B., Flaiz, M., Böer, T., Lüschen, A., Höfele, F., Baur, K. S., Molitor, B., Kröly, C., Wang, M., Zhang, Q., Fan, Y., Chao, W., Daniel, R., Li, F., Basen, M., Müller, V., Angenent, L. T., Sousa, D. Z., & Bengelsdorf, F. R. (2025). Advanced aspects of acetogens. Bioresource Technology, 427, Article 131913. https://doi.org/10.1016/j.biortech.2024.131913

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title = "Advanced aspects of acetogens",

abstract = "Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide reduction and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is the Wood-Ljungdahl pathway. This review offers a comprehensive overview of the latest discoveries that are related to acetogens. It delves into a variety of topics, including newly isolated acetogens, their taxonomy and physiology and highlights novel metabolic properties. Additionally, it explores metabolic engineering strategies that are designed to expand the product range of acetogens or to understand specific traits of their metabolism. Lastly, the review presents innovative gas fermentation techniques within the context of industrial applications.",

author = "Anja Poehlein and Benjamin Zeldes and Maximilian Flaiz and Tim B{\"o}er and Alina L{\"u}schen and Franziska H{\"o}fele and Baur, {Kira S.} and Bastian Molitor and Christian Kr{\"o}ly and Meng Wang and Quan Zhang and Yixuan Fan and Wei Chao and Rolf Daniel and Fuli Li and Mirko Basen and Volker M{\"u}ller and Angenent, {Largus T.} and Sousa, {Diana Z.} and Bengelsdorf, {Frank R.}",

year = "2025",

month = jul,

doi = "10.1016/j.biortech.2024.131913",

language = "English",

volume = "427",

journal = "Bioresource Technology",

issn = "0960-8524",

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T1 - Advanced aspects of acetogens

AU - Poehlein, Anja

AU - Zeldes, Benjamin

AU - Flaiz, Maximilian

AU - Böer, Tim

AU - Lüschen, Alina

AU - Höfele, Franziska

AU - Baur, Kira S.

AU - Molitor, Bastian

AU - Kröly, Christian

AU - Wang, Meng

AU - Zhang, Quan

AU - Fan, Yixuan

AU - Chao, Wei

AU - Daniel, Rolf

AU - Li, Fuli

AU - Basen, Mirko

AU - Müller, Volker

AU - Angenent, Largus T.

AU - Sousa, Diana Z.

AU - Bengelsdorf, Frank R.

PY - 2025/7

Y1 - 2025/7

N2 - Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide reduction and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is the Wood-Ljungdahl pathway. This review offers a comprehensive overview of the latest discoveries that are related to acetogens. It delves into a variety of topics, including newly isolated acetogens, their taxonomy and physiology and highlights novel metabolic properties. Additionally, it explores metabolic engineering strategies that are designed to expand the product range of acetogens or to understand specific traits of their metabolism. Lastly, the review presents innovative gas fermentation techniques within the context of industrial applications.

AB - Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide reduction and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is the Wood-Ljungdahl pathway. This review offers a comprehensive overview of the latest discoveries that are related to acetogens. It delves into a variety of topics, including newly isolated acetogens, their taxonomy and physiology and highlights novel metabolic properties. Additionally, it explores metabolic engineering strategies that are designed to expand the product range of acetogens or to understand specific traits of their metabolism. Lastly, the review presents innovative gas fermentation techniques within the context of industrial applications.

U2 - 10.1016/j.biortech.2024.131913

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SN - 0960-8524

VL - 427

JO - Bioresource Technology

JF - Bioresource Technology

M1 - 131913

ER -

Advanced aspects of acetogens

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