Advanced analytical strategies for measuring free bioactive milk sugars: from composition and concentrations to human metabolic response

Aifric O’Sullivan, Jaime Salcedo, Josep Rubert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Our daily food intake provides the nutrients to maintain health. However, in addition to the nutritional values, food can promote health and be beneficial in preventing diseases. Human milk is a unique food source that contains essential nutrients in the right balance and other bioactive factors that make it the ideal food for all healthy term infants. Human milk oligosaccharides (HMOs) play an important role in health, at several levels: acting as prebiotics promoting the growth of beneficial bacterial strains, preventing the growth of pathogenic bacteria in the intestine, and modulating the immune response against bacterial infections. However, despite their biological relevance and the advances made in the analytical field, very few studies have been carried out to better understand HMOs bioactivity mechanisms or to examine human metabolic response to dietary supplementation. This review describes the state-of-the-art of glycomics strategies, recent analytical methods, and future trends for the identification and discovery of bioactive sugars, the known mechanisms of action, and discusses findings of some recent human intervention trials.

Original languageEnglish
Pages (from-to)3445-3462
Number of pages18
JournalAnalytical and Bioanalytical Chemistry
Volume410
Issue number15
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

Keywords

  • Glycomics
  • Human milk oligosaccharides
  • Ion mobility
  • Mass spectrometry
  • Nutrition

Fingerprint Dive into the research topics of 'Advanced analytical strategies for measuring free bioactive milk sugars: from composition and concentrations to human metabolic response'. Together they form a unique fingerprint.

Cite this