Adipokines in the prevention of type 2 diabetes: The effect of a long-term lifestyle intervention

E.E. Blaak, C. Roumen, E. Corpeleijn, W.H.M. Saris, E.J.M. Feskens

Research output: Contribution to journalAbstractAcademic

Abstract

Background and aims: We investigated the effect of a 4.2 year lifestyle intervention according to general recommendations on circulating adipokine concentrations and inflammation markers in subjects at risk for diabetes as well as the potential of leptin, adiponectin, resistin, plasminogen activator inhibitor 1 (PAI-1) and Complement factor 3 (C3) as biomarkers for lifestyleinduced improvements in glucose metabolism and insulin resistance. Materials and methods: In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 men and women with impaired glucose olerance (IGT) were randomized to either a combined diet-and-exercise intervention (INT) or a control program (CON). At baseline and at the end of the study (after 4 or 6 years) adipokines and inflammation were measured in addition to performance of an oral glucose tolerance test, an exercise test, and anthropometric measurements. At the end of the study, complete data of 92 subjects (49 INT,43 CON) were obtained. Results: Lifestyle intervention increased carbohydrate intake, improved maximal aerobic capacity (VO2 max) and reduced diabetes incidence by 31 % (pall
Original languageEnglish
Pages (from-to)S148
JournalDiabetologia
Volume51
Issue numberSuppl. 1
Publication statusPublished - 2008

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