Adaptation of protein metabolism to changes in lysine intake in growing pigs

J.J.G.C. van den Borne, S. Borgijink, J. Dijkstra, W.J.J. Gerrits

Research output: Contribution to journalAbstractAcademic


The indicator amino acid technique is a well-known tool to estimate amino acid requirements within a subject. It involves measurement of responses in protein metabolism to step-wise changes in amino acid imbalance. The objective of this experiment was to compare lysine requirement estimates from increasing vs. decreasing titration strategies, and to study adaptive responses to changes in lysine intake. Pigs (n=14; 27.1±0.2 kg) were housed in metabolism crates and assigned to one of two treatments, with digestible lysine intake either increasing from 4.7 to 14.0 g/kg (INCR) or decreasing from 14.0 to 4.7 g/kg feed (DECR) in 7 equidistant steps, at identical intakes of other nutrients. Each step lasted 4d. Four complete 24h urine collections were performed from all pigs for each lysine level. Total urinary N and urea excretion were determined for all 24h collections. [15N]glycine was provided orally at d 3 of each lysine level and enrichment was measured in urinary urea. A linear-plateau model was fitted to N efficiency (in %) data. Treatment effects on slopes and inflection point estimates of the model were then analyzed statistically. Based on the F-test, for 11 of the 14 pigs the linear-plateau model fitted data better (P
Original languageEnglish
Pages (from-to)178 (203)
JournalJournal of Animal Science
Issue numberE-Suppl. 2
Publication statusPublished - 2008

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