Active surveillance for scrapie in the Netherlands: effect of a breeding programme on the prevalence of scrapie in sheep (2002-2010)? = Acht jaar actieve scrapie-surveillance in Nederland: het effect van het fokprogramma op de prevalentie van schrapie bij het schaap (2002-2010)

M.B. Melchior, T.H.J. Hagenaars, A. Davidse, L.J.M. van Keulen, A. Bossers, F.G. van Zijderveld

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The susceptibility of sheep to scrapie is modulated by the prion protein (PrP) genotype of the animal. An ambitious voluntary scrapie control programme was started in the Netherlands in 1998, based on selection of rams with theARR/ARR genotype for breeding. This programme was followed by an obligatory programme in 2004; the programme has been voluntary since 2007. We monitored the prevalence of PrP genotype frequencies and the prevalence of scrapie in the Dutch sheep population between 2002 and June 2010. Results showed that selection for scrapie-resistant sheep resulted in an increase in the ARR allele frequency in the Dutch national flock from 37.5% in 2005 to 61.4% in 2009. Moreover, surveillance data showed that there was a significant decrease in the prevalence of scrapie a few years after the start of the obligatory breeding programme, from more than 0.2% in 2004 to 0.015% in 2009. This decrease is a consequence of the increased number of scrapie-resistant sheep in the Dutch sheep population. To date, the results and the models based on the data show that the selective breeding programme should be continued for several years in order to successfully eradicate scrapie. It will be important to monitor the PrP frequency and scrapie prevalence in the Dutch sheep population in the coming years.
LanguageEnglish
Pages84-93
JournalTijdschrift voor Diergeneeskunde
Volume136
Issue number2
Publication statusPublished - 2011

Fingerprint

Scrapie
scrapie
Netherlands
Breeding
Sheep
sheep
monitoring
breeding
prions
Genotype
genotype
Population
selection methods
Gene Frequency
rams
gene frequency
flocks

Keywords

  • bovine spongiform encephalopathy
  • in-vitro conversion
  • natural scrapie
  • prion protein
  • immunohistochemical detection
  • experimental flock
  • bse
  • transmission
  • prp
  • susceptibility

Cite this

@article{e749f19671dc459fbb9a9b83e6d21ce8,
title = "Active surveillance for scrapie in the Netherlands: effect of a breeding programme on the prevalence of scrapie in sheep (2002-2010)? = Acht jaar actieve scrapie-surveillance in Nederland: het effect van het fokprogramma op de prevalentie van schrapie bij het schaap (2002-2010)",
abstract = "The susceptibility of sheep to scrapie is modulated by the prion protein (PrP) genotype of the animal. An ambitious voluntary scrapie control programme was started in the Netherlands in 1998, based on selection of rams with theARR/ARR genotype for breeding. This programme was followed by an obligatory programme in 2004; the programme has been voluntary since 2007. We monitored the prevalence of PrP genotype frequencies and the prevalence of scrapie in the Dutch sheep population between 2002 and June 2010. Results showed that selection for scrapie-resistant sheep resulted in an increase in the ARR allele frequency in the Dutch national flock from 37.5{\%} in 2005 to 61.4{\%} in 2009. Moreover, surveillance data showed that there was a significant decrease in the prevalence of scrapie a few years after the start of the obligatory breeding programme, from more than 0.2{\%} in 2004 to 0.015{\%} in 2009. This decrease is a consequence of the increased number of scrapie-resistant sheep in the Dutch sheep population. To date, the results and the models based on the data show that the selective breeding programme should be continued for several years in order to successfully eradicate scrapie. It will be important to monitor the PrP frequency and scrapie prevalence in the Dutch sheep population in the coming years.",
keywords = "bovine spongiform encephalopathy, in-vitro conversion, natural scrapie, prion protein, immunohistochemical detection, experimental flock, bse, transmission, prp, susceptibility",
author = "M.B. Melchior and T.H.J. Hagenaars and A. Davidse and {van Keulen}, L.J.M. and A. Bossers and {van Zijderveld}, F.G.",
year = "2011",
language = "English",
volume = "136",
pages = "84--93",
journal = "Tijdschrift voor Diergeneeskunde",
issn = "0040-7453",
publisher = "Koninklijke Nederlandse Maatschappij voor Diergeneeskunde",
number = "2",

}

TY - JOUR

T1 - Active surveillance for scrapie in the Netherlands: effect of a breeding programme on the prevalence of scrapie in sheep (2002-2010)? = Acht jaar actieve scrapie-surveillance in Nederland: het effect van het fokprogramma op de prevalentie van schrapie bij het schaap (2002-2010)

AU - Melchior, M.B.

AU - Hagenaars, T.H.J.

AU - Davidse, A.

AU - van Keulen, L.J.M.

AU - Bossers, A.

AU - van Zijderveld, F.G.

PY - 2011

Y1 - 2011

N2 - The susceptibility of sheep to scrapie is modulated by the prion protein (PrP) genotype of the animal. An ambitious voluntary scrapie control programme was started in the Netherlands in 1998, based on selection of rams with theARR/ARR genotype for breeding. This programme was followed by an obligatory programme in 2004; the programme has been voluntary since 2007. We monitored the prevalence of PrP genotype frequencies and the prevalence of scrapie in the Dutch sheep population between 2002 and June 2010. Results showed that selection for scrapie-resistant sheep resulted in an increase in the ARR allele frequency in the Dutch national flock from 37.5% in 2005 to 61.4% in 2009. Moreover, surveillance data showed that there was a significant decrease in the prevalence of scrapie a few years after the start of the obligatory breeding programme, from more than 0.2% in 2004 to 0.015% in 2009. This decrease is a consequence of the increased number of scrapie-resistant sheep in the Dutch sheep population. To date, the results and the models based on the data show that the selective breeding programme should be continued for several years in order to successfully eradicate scrapie. It will be important to monitor the PrP frequency and scrapie prevalence in the Dutch sheep population in the coming years.

AB - The susceptibility of sheep to scrapie is modulated by the prion protein (PrP) genotype of the animal. An ambitious voluntary scrapie control programme was started in the Netherlands in 1998, based on selection of rams with theARR/ARR genotype for breeding. This programme was followed by an obligatory programme in 2004; the programme has been voluntary since 2007. We monitored the prevalence of PrP genotype frequencies and the prevalence of scrapie in the Dutch sheep population between 2002 and June 2010. Results showed that selection for scrapie-resistant sheep resulted in an increase in the ARR allele frequency in the Dutch national flock from 37.5% in 2005 to 61.4% in 2009. Moreover, surveillance data showed that there was a significant decrease in the prevalence of scrapie a few years after the start of the obligatory breeding programme, from more than 0.2% in 2004 to 0.015% in 2009. This decrease is a consequence of the increased number of scrapie-resistant sheep in the Dutch sheep population. To date, the results and the models based on the data show that the selective breeding programme should be continued for several years in order to successfully eradicate scrapie. It will be important to monitor the PrP frequency and scrapie prevalence in the Dutch sheep population in the coming years.

KW - bovine spongiform encephalopathy

KW - in-vitro conversion

KW - natural scrapie

KW - prion protein

KW - immunohistochemical detection

KW - experimental flock

KW - bse

KW - transmission

KW - prp

KW - susceptibility

M3 - Article

VL - 136

SP - 84

EP - 93

JO - Tijdschrift voor Diergeneeskunde

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JF - Tijdschrift voor Diergeneeskunde

SN - 0040-7453

IS - 2

ER -