Acquisition and data-processing parameters in suspect screening of antibiotics using LC-HRMS

L.J.M. Jansen; R. Nijssen; Y.J.C. Bolck; R.S. Wegh; M.G.M. van de Schans; B.J.A. Berendsen

Acquisition and data-processing parameters in suspect screening of antibiotics using LC-HRMS

L.J.M. Jansen, R. Nijssen, Y.J.C. Bolck, R.S. Wegh, M.G.M. van de Schans, B.J.A. Berendsen

Research output: Contribution to conference › Poster › Academic

Abstract

For years, targeted analysis by LC-MS/MS has been used to monitor specific veterinary drugs in products of animal origin. Now, monitoring strategies start shifting towards a non-targeted, more risk-based approach, as is mandatory according to the official controls regulation (EU) 2017/625 1. This shift has pushed the utilization of high-resolution mass spectrometry (HRMS) and suspect screening, an approach for processing untargeted data in which reference standards are not a necessity. 2,3 Studies that investigate the performance of suspect screening workflow strategies for the detection of veterinary drugs in complex matrices are however still scarce. In this work, a systematic assessment was carried out in eather meal matrix, using both an in-house suspect list and the online mzCloudTM database.

Original language	English
Publication status	Published - 23 May 2022
Event	EuroResidue Conference IX 2022 - Hotel de Ruwenberg, St. Michielsgestel, Netherlands Duration: 23 May 2022 → 25 May 2022 https://www.euroresidue.eu/

Conference

Conference	EuroResidue Conference IX 2022
Country/Territory	Netherlands
City	St. Michielsgestel
Period	23/05/22 → 25/05/22
Internet address	https://www.euroresidue.eu/

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https://edepot.wur.nl/571846

1 Article

Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS
Jansen, L. J. M., Nijssen, R., Bolck, Y. J. C., Wegh, R. S., van de Schans, M. G. M. & Berendsen, B. J. A., 1 Feb 2022, In: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 39, 2, p. 272-284
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
5 Citations (Scopus)

Cite this

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title = "Acquisition and data-processing parameters in suspect screening of antibiotics using LC-HRMS",

abstract = "For years, targeted analysis by LC-MS/MS has been used to monitor specific veterinary drugs in products of animal origin. Now, monitoring strategies start shifting towards a non-targeted, more risk-based approach, as is mandatory according to the official controls regulation (EU) 2017/625 1. This shift has pushed the utilization of high-resolution mass spectrometry (HRMS) and suspect screening, an approach for processing untargeted data in which reference standards are not a necessity. 2,3 Studies that investigate the performance of suspect screening workflow strategies for the detection of veterinary drugs in complex matrices are however still scarce. In this work, a systematic assessment was carried out in eather meal matrix, using both an in-house suspect list and the online mzCloudTM database.",

author = "L.J.M. Jansen and R. Nijssen and Y.J.C. Bolck and R.S. Wegh and {van de Schans}, M.G.M. and B.J.A. Berendsen",

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T1 - Acquisition and data-processing parameters in suspect screening of antibiotics using LC-HRMS

AU - Jansen, L.J.M.

AU - Nijssen, R.

AU - Bolck, Y.J.C.

AU - Wegh, R.S.

AU - van de Schans, M.G.M.

AU - Berendsen, B.J.A.

PY - 2022/5/23

Y1 - 2022/5/23

N2 - For years, targeted analysis by LC-MS/MS has been used to monitor specific veterinary drugs in products of animal origin. Now, monitoring strategies start shifting towards a non-targeted, more risk-based approach, as is mandatory according to the official controls regulation (EU) 2017/625 1. This shift has pushed the utilization of high-resolution mass spectrometry (HRMS) and suspect screening, an approach for processing untargeted data in which reference standards are not a necessity. 2,3 Studies that investigate the performance of suspect screening workflow strategies for the detection of veterinary drugs in complex matrices are however still scarce. In this work, a systematic assessment was carried out in eather meal matrix, using both an in-house suspect list and the online mzCloudTM database.

AB - For years, targeted analysis by LC-MS/MS has been used to monitor specific veterinary drugs in products of animal origin. Now, monitoring strategies start shifting towards a non-targeted, more risk-based approach, as is mandatory according to the official controls regulation (EU) 2017/625 1. This shift has pushed the utilization of high-resolution mass spectrometry (HRMS) and suspect screening, an approach for processing untargeted data in which reference standards are not a necessity. 2,3 Studies that investigate the performance of suspect screening workflow strategies for the detection of veterinary drugs in complex matrices are however still scarce. In this work, a systematic assessment was carried out in eather meal matrix, using both an in-house suspect list and the online mzCloudTM database.

M3 - Poster

T2 - EuroResidue Conference IX 2022

Y2 - 23 May 2022 through 25 May 2022

ER -

Acquisition and data-processing parameters in suspect screening of antibiotics using LC-HRMS

Abstract

Conference

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Research output

Systematic assessment of acquisition and data-processing parameters in the suspect screening of veterinary drugs in archive matrices using LC-HRMS

Cite this