Accumulation of podophyllotoxin and related lignans in cell suspension cultures of Linum album

T. Smollny, H. Wichers, S. Kalenberg, A. Shahsavari, M. Petersen, A.W. Alfermann

    Research output: Contribution to journalArticleAcademicpeer-review

    71 Citations (Scopus)

    Abstract

    Cell suspension cultures of Linum album were established, which were able to synthesize and accumulate lignans. Podophyllotoxin and 5-methoxypodophyllotoxin were the main products and were present as glycosides, together with small amounts of deoxypodophyllotoxin, 5′-demethoxy-5-methoxypodophyllotoxin, lariciresinol, pinoresinol, matairesinol, α- and β-peltatin, as well as the monolignol glucoside, coniferin. In dark and light grown cultures, maximal product yields of lignans of up to 0.2% and 0.5% of the dry weight, respectively, were achieved, mainly consisting of podophyllotoxin.
    Original languageEnglish
    Pages (from-to)975-979
    JournalPhytochemistry
    Volume48
    Issue number6
    DOIs
    Publication statusPublished - 1998

    Keywords

    • 5- Methoxypodophyllotoxin
    • Biosynthesis
    • Coniferin
    • Lignans
    • Linaceae
    • Linum album
    • Plant cell cultures
    • Podophyllotoxin
    • White flax

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