A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch

Cyrille Saintenac; Florence Cambon; Lamia Aouini; Els Verstappen; Seyed Mahmoud Tabib Ghaffary; Théo Poucet; William Marande; Hélène Berges; Steven Xu; Maëlle Jaouannet; Bruno Favery; Julien Alassimone; Andrea Sánchez-Vallet; Justin Faris; Gert Kema; Oliver Robert; Thierry Langin

doi:10.1038/s41467-020-20685-0

A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch

Cyrille Saintenac^*, Florence Cambon, Lamia Aouini, Els Verstappen, Seyed Mahmoud Tabib Ghaffary, Théo Poucet, William Marande, Hélène Berges, Steven Xu, Maëlle Jaouannet, Bruno Favery, Julien Alassimone, Andrea Sánchez-Vallet, Justin Faris, Gert Kema, Oliver Robert, Thierry Langin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.

Original language	English
Article number	433
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-20685-0
Publication status	Published - 19 Jan 2021

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Saintenac, C., Cambon, F., Aouini, L., Verstappen, E., Ghaffary, S. M. T., Poucet, T., Marande, W., Berges, H., Xu, S., Jaouannet, M., Favery, B., Alassimone, J., Sánchez-Vallet, A., Faris, J., Kema, G., Robert, O., & Langin, T. (2021). A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch. Nature Communications, 12(1), Article 433. https://doi.org/10.1038/s41467-020-20685-0

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abstract = "The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.",

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Saintenac, C, Cambon, F, Aouini, L, Verstappen, E, Ghaffary, SMT, Poucet, T, Marande, W, Berges, H, Xu, S, Jaouannet, M, Favery, B, Alassimone, J, Sánchez-Vallet, A, Faris, J, Kema, G, Robert, O & Langin, T 2021, 'A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch', Nature Communications, vol. 12, no. 1, 433. https://doi.org/10.1038/s41467-020-20685-0

TY - JOUR

T1 - A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch

AU - Saintenac, Cyrille

AU - Cambon, Florence

AU - Aouini, Lamia

AU - Verstappen, Els

AU - Ghaffary, Seyed Mahmoud Tabib

AU - Poucet, Théo

AU - Marande, William

AU - Berges, Hélène

AU - Xu, Steven

AU - Jaouannet, Maëlle

AU - Favery, Bruno

AU - Alassimone, Julien

AU - Sánchez-Vallet, Andrea

AU - Faris, Justin

AU - Kema, Gert

AU - Robert, Oliver

AU - Langin, Thierry

PY - 2021/1/19

Y1 - 2021/1/19

N2 - The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.

AB - The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.

U2 - 10.1038/s41467-020-20685-0

DO - 10.1038/s41467-020-20685-0

M3 - Article

C2 - 33469010

AN - SCOPUS:85099530485

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 433

ER -

A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch

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