A wheat cysteine-rich receptor-like kinase confers broad-spectrum resistance against Septoria tritici blotch

Cyrille Saintenac*, Florence Cambon, Lamia Aouini, Els Verstappen, Seyed Mahmoud Tabib Ghaffary, Théo Poucet, William Marande, Hélène Berges, Steven Xu, Maëlle Jaouannet, Bruno Favery, Julien Alassimone, Andrea Sánchez-Vallet, Justin Faris, Gert Kema, Oliver Robert, Thierry Langin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.

Original languageEnglish
Article number433
JournalNature Communications
Volume12
Issue number1
DOIs
Publication statusPublished - 19 Jan 2021

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