A toxicokinetic model for the carry-over of dioxins and PCBs from feed and soil to eggs

J. van Eijkeren, M. Zeilmaker, C.A. Kan, W.A. Traag, L.A.P. Hoogenboom

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

A mathematical model for the kinetics of carry-over of dioxins and dioxin-like PCBs from feed mixed with contaminated oil to eggs has been developed. This model incorporates uptake of the compounds over the gut wall and their subsequent transport by blood, distribution over the body, hepatic metabolism and excretion through egg yolk fat. The model is analysed with respect to the possibility of identifying as yet unknown model parameters by fitting these to the experimental data. The model was fitted to the experimental data on the carry-over from feed to eggs. The calibrated model was applied to calculate the steady-state concentrations in eggs which were compared to European Maximum Residue Levels for dioxins in feed and eggs, showing that these limits do not match. The feed limit of 0.75ngTEQ/kg should be reduced to about 0.17ngTEQ/kg in order to guarantee egg levels below the residue limit of 3pgTEQ/g fat. Experimental results of carry-over from contaminated soil were used to estimate the absorption of dioxin-like compounds from soils as compared to the absorption from feed, resulting in a value around 40 to 60% absorption from soil as compared to around 90% absorption from feed
Original languageEnglish
Pages (from-to)509-517
JournalFood Additives and Contaminants
Volume23
Issue number5
DOIs
Publication statusPublished - 2006

Keywords

  • drug residue uptake
  • yolks
  • ampicillin

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