A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics

Myrna M.T. de Rooij, Jeroen P.G. van Leuken, Arno Swart, Mirjam E.E. Kretzschmar, Mirjam Nielen, Aline A. de Koeijer, Ingmar Janse, Inge M. Wouters, Dick J.J. Heederik

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella burnetii and reflects these outcomes in relation to other scientific Q fever studies worldwide. We have identified lessons learned and remaining knowledge gaps. This synthesis was structured according to the four steps of quantitative microbial risk assessment (QMRA): (a) Rapid source identification was improved by newly developed techniques using mathematical disease modelling; (b) source characterization efforts improved knowledge but did not provide accurate C. burnetii emission patterns; (c) ambient air sampling, dispersion and spatial modelling promoted exposure assessment; and (d) risk characterization was enabled by applying refined dose–response analyses. The results may support proper and timely risk assessment and risk management during future outbreaks, provided that accurate and structured data are available and exchanged readily between responsible actors.

LanguageEnglish
Pages14-25
JournalZoonoses and Public Health
Volume66
Issue number1
Early online date6 Nov 2018
DOIs
Publication statusPublished - Feb 2019

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Coxiella burnetii
Q fever
Q Fever
airborne transmission
microbiological risk assessment
risk characterization
quantitative risk assessment
exposure assessment
synthesis
risk management
Risk Management
research programs
Netherlands
risk assessment
dose response
Disease Outbreaks
Air
Outcome Assessment (Health Care)
air
Research

Keywords

  • airborne exposure
  • Coxiella burnetii
  • epidemiology
  • Q fever
  • risk assessment
  • spatial analysis

Cite this

de Rooij, M. M. T., van Leuken, J. P. G., Swart, A., Kretzschmar, M. E. E., Nielen, M., de Koeijer, A. A., ... Heederik, D. J. J. (2019). A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics. Zoonoses and Public Health, 66(1), 14-25. https://doi.org/10.1111/zph.12534
de Rooij, Myrna M.T. ; van Leuken, Jeroen P.G. ; Swart, Arno ; Kretzschmar, Mirjam E.E. ; Nielen, Mirjam ; de Koeijer, Aline A. ; Janse, Ingmar ; Wouters, Inge M. ; Heederik, Dick J.J. / A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics. In: Zoonoses and Public Health. 2019 ; Vol. 66, No. 1. pp. 14-25.
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de Rooij, MMT, van Leuken, JPG, Swart, A, Kretzschmar, MEE, Nielen, M, de Koeijer, AA, Janse, I, Wouters, IM & Heederik, DJJ 2019, 'A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics', Zoonoses and Public Health, vol. 66, no. 1, pp. 14-25. https://doi.org/10.1111/zph.12534

A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics. / de Rooij, Myrna M.T.; van Leuken, Jeroen P.G.; Swart, Arno; Kretzschmar, Mirjam E.E.; Nielen, Mirjam; de Koeijer, Aline A.; Janse, Ingmar; Wouters, Inge M.; Heederik, Dick J.J.

In: Zoonoses and Public Health, Vol. 66, No. 1, 02.2019, p. 14-25.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Nielen, Mirjam

AU - de Koeijer, Aline A.

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