A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"

I.M. van Oort, D.E.G. Kok, L.A. Kiemeney, C.A. Hulsbergen-van de Kaa, J.A. Witjes

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Objective: Small volume prostate cancers (0.10 ng/ml. Results: In the total group, the median age at the time Of Surgery was 62.7 years (42.4-73.4) and the median preoperative PSA level was 8.0 ng/ml. Patients with InsigPC had Gleason scores of 4 in 7%, 5 in 37%, and 6 in 56%. Positive surgical margins were identified in 13 (15.9%) svPC and in 8 (12.7%) InsigPC specimens. The 5-year risk of BCR for the svPC group and the insigPC group was 10% (95% Cl 2-18%, 7 and 5 patients, respectively) vs. 35% (95% CI 29-41%) in the rest of the cohort (log rank P = 0.001). Conclusion: Patients with svPC and patients with InsigPC have a significantly lower risk of BCR. However, even in this seemingly very favorable patient group, I in 10 patients will develop a BCR after RP. Therefore, new studies are needed to examine what the prognostic relevance is of small-volume tumors. (C) 2009 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)509-513
JournalUrology Oncology: Seminars and Original Investigations
Volume27
Issue number5
DOIs
Publication statusPublished - 2009

Keywords

  • retropubic prostatectomy
  • independent predictor
  • clinical-significance
  • needle-biopsy
  • cancer
  • specimens
  • men
  • progression
  • nomogram
  • features

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