A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"

I.M. van Oort; D.E.G. Kok; L.A. Kiemeney; C.A. Hulsbergen-van de Kaa; J.A. Witjes

doi:10.1016/j.urolonc.2008.04.014

A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"

I.M. van Oort, D.E.G. Kok, L.A. Kiemeney, C.A. Hulsbergen-van de Kaa, J.A. Witjes

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Objective: Small volume prostate cancers (0.10 ng/ml. Results: In the total group, the median age at the time Of Surgery was 62.7 years (42.4-73.4) and the median preoperative PSA level was 8.0 ng/ml. Patients with InsigPC had Gleason scores of 4 in 7%, 5 in 37%, and 6 in 56%. Positive surgical margins were identified in 13 (15.9%) svPC and in 8 (12.7%) InsigPC specimens. The 5-year risk of BCR for the svPC group and the insigPC group was 10% (95% Cl 2-18%, 7 and 5 patients, respectively) vs. 35% (95% CI 29-41%) in the rest of the cohort (log rank P = 0.001). Conclusion: Patients with svPC and patients with InsigPC have a significantly lower risk of BCR. However, even in this seemingly very favorable patient group, I in 10 patients will develop a BCR after RP. Therefore, new studies are needed to examine what the prognostic relevance is of small-volume tumors. (C) 2009 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	509-513
Journal	Urology Oncology: Seminars and Original Investigations
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.urolonc.2008.04.014
Publication status	Published - 2009

Keywords

retropubic prostatectomy
independent predictor
clinical-significance
needle-biopsy
cancer
specimens
men
progression
nomogram
features

Access to Document

10.1016/j.urolonc.2008.04.014

Fingerprint Dive into the research topics of 'A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"'. Together they form a unique fingerprint.

Cite this

van Oort, I. M., Kok, D. E. G., Kiemeney, L. A., Hulsbergen-van de Kaa, C. A., & Witjes, J. A. (2009). A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant". Urology Oncology: Seminars and Original Investigations, 27(5), 509-513. https://doi.org/10.1016/j.urolonc.2008.04.014

@article{8235698de581470790ce908a8b758985,

title = "A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or {"}insignificant{"}",

abstract = "Objective: Small volume prostate cancers (0.10 ng/ml. Results: In the total group, the median age at the time Of Surgery was 62.7 years (42.4-73.4) and the median preoperative PSA level was 8.0 ng/ml. Patients with InsigPC had Gleason scores of 4 in 7%, 5 in 37%, and 6 in 56%. Positive surgical margins were identified in 13 (15.9%) svPC and in 8 (12.7%) InsigPC specimens. The 5-year risk of BCR for the svPC group and the insigPC group was 10% (95% Cl 2-18%, 7 and 5 patients, respectively) vs. 35% (95% CI 29-41%) in the rest of the cohort (log rank P = 0.001). Conclusion: Patients with svPC and patients with InsigPC have a significantly lower risk of BCR. However, even in this seemingly very favorable patient group, I in 10 patients will develop a BCR after RP. Therefore, new studies are needed to examine what the prognostic relevance is of small-volume tumors. (C) 2009 Elsevier Inc. All rights reserved.",

keywords = "retropubic prostatectomy, independent predictor, clinical-significance, needle-biopsy, cancer, specimens, men, progression, nomogram, features",

author = "{van Oort}, I.M. and D.E.G. Kok and L.A. Kiemeney and {Hulsbergen-van de Kaa}, C.A. and J.A. Witjes",

note = "Online first",

year = "2009",

doi = "10.1016/j.urolonc.2008.04.014",

language = "English",

volume = "27",

pages = "509--513",

journal = "Urology Oncology: Seminars and Original Investigations",

issn = "1078-1439",

publisher = "Elsevier",

number = "5",

}

van Oort, IM, Kok, DEG, Kiemeney, LA, Hulsbergen-van de Kaa, CA & Witjes, JA 2009, 'A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"', Urology Oncology: Seminars and Original Investigations, vol. 27, no. 5, pp. 509-513. https://doi.org/10.1016/j.urolonc.2008.04.014

A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant". / van Oort, I.M.; Kok, D.E.G.; Kiemeney, L.A.; Hulsbergen-van de Kaa, C.A.; Witjes, J.A.

In: Urology Oncology: Seminars and Original Investigations, Vol. 27, No. 5, 2009, p. 509-513.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"

AU - van Oort, I.M.

AU - Kok, D.E.G.

AU - Kiemeney, L.A.

AU - Hulsbergen-van de Kaa, C.A.

AU - Witjes, J.A.

N1 - Online first

PY - 2009

Y1 - 2009

N2 - Objective: Small volume prostate cancers (0.10 ng/ml. Results: In the total group, the median age at the time Of Surgery was 62.7 years (42.4-73.4) and the median preoperative PSA level was 8.0 ng/ml. Patients with InsigPC had Gleason scores of 4 in 7%, 5 in 37%, and 6 in 56%. Positive surgical margins were identified in 13 (15.9%) svPC and in 8 (12.7%) InsigPC specimens. The 5-year risk of BCR for the svPC group and the insigPC group was 10% (95% Cl 2-18%, 7 and 5 patients, respectively) vs. 35% (95% CI 29-41%) in the rest of the cohort (log rank P = 0.001). Conclusion: Patients with svPC and patients with InsigPC have a significantly lower risk of BCR. However, even in this seemingly very favorable patient group, I in 10 patients will develop a BCR after RP. Therefore, new studies are needed to examine what the prognostic relevance is of small-volume tumors. (C) 2009 Elsevier Inc. All rights reserved.

AB - Objective: Small volume prostate cancers (0.10 ng/ml. Results: In the total group, the median age at the time Of Surgery was 62.7 years (42.4-73.4) and the median preoperative PSA level was 8.0 ng/ml. Patients with InsigPC had Gleason scores of 4 in 7%, 5 in 37%, and 6 in 56%. Positive surgical margins were identified in 13 (15.9%) svPC and in 8 (12.7%) InsigPC specimens. The 5-year risk of BCR for the svPC group and the insigPC group was 10% (95% Cl 2-18%, 7 and 5 patients, respectively) vs. 35% (95% CI 29-41%) in the rest of the cohort (log rank P = 0.001). Conclusion: Patients with svPC and patients with InsigPC have a significantly lower risk of BCR. However, even in this seemingly very favorable patient group, I in 10 patients will develop a BCR after RP. Therefore, new studies are needed to examine what the prognostic relevance is of small-volume tumors. (C) 2009 Elsevier Inc. All rights reserved.

KW - retropubic prostatectomy

KW - independent predictor

KW - clinical-significance

KW - needle-biopsy

KW - cancer

KW - specimens

KW - men

KW - progression

KW - nomogram

KW - features

U2 - 10.1016/j.urolonc.2008.04.014

DO - 10.1016/j.urolonc.2008.04.014

M3 - Article

VL - 27

SP - 509

EP - 513

JO - Urology Oncology: Seminars and Original Investigations

JF - Urology Oncology: Seminars and Original Investigations

SN - 1078-1439

IS - 5

ER -