A role for TLR10 in obesity and adipose tissue morphology

Lily Boutens, Andreea Manuela Mirea, Inge van den Munckhof, Marije Doppenberg-Oosting, Martin Jaeger, Anneke Hijmans, Mihai G. Netea, Leo A.B. Joosten*, Rinke Stienstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Toll like receptors (TLRs) are expressed in adipose tissue and promote adipose tissue inflammation during obesity. Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity. In order to assess whether TLR10-induced inhibition of inflammation may be protective during the development of obesity and metabolic abnormalities we used transgenic human TLR10 mice (hTLR10tg) and wild type (WT) controls on a C57B6J background. HFD-feeding enhanced TLR10 expression in the adipose tissue, and HFD-fed hTLR10tg mice displayed reduced adipocyte size, adipose tissue weight, and a trend toward lower plasma insulin levels compared to WT mice. In humans, obese individuals with polymorphisms in the TLR10 gene displayed reduced macrophage infiltration in the adipose tissue accompanied by a trend to lower leptin levels and higher adiponectin levels in plasma. In healthy individuals with the same polymorphisms in the TLR10 gene we did not observe any difference in plasma concentrations of leptin and adiponectin. We conclude that TLR10 impacts adipose tissue morphology in obesity. Larger studies in humans are warranted to assess its potential value as therapeutic target in metabolic syndrome and type 2 diabetes.
Original languageEnglish
Pages (from-to)205-212
JournalCytokine
Volume108
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Adipose tissue
  • Inflammation
  • Obesity
  • SNPs
  • TLR10

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